what-is-the-consequence-of-histidine-57-acting-as-an-acid-during-the-removal-of-

Question

What is the consequence of histidine 57 acting as an acid during the removal of the leaving group in the acylation phase?

Accepted Answer

It donates a proton to facilitate the cleavage of the peptide bond.

Answer

It increases the nucleophilicity of serine 195.

Answer

It accepts a proton to stabilize the tetrahedral intermediate.

Answer

It forms a covalent bond with the substrate.