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General Biology Exam 1 Study Guide: Foundations, Chemistry of Life, and Macromolecules

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Concepts to Know and Understand

Seven Properties of Life and Hierarchy of Organization

Biology is the study of living organisms, which share certain properties and are organized in a hierarchical manner.

  • Properties of Life: Living things exhibit order, regulation, growth and development, energy processing, response to the environment, reproduction, and evolutionary adaptation.

  • Hierarchy of Organization: Life is organized from the smallest to largest as follows: moleculeorganellecelltissueorganorgan systemorganismpopulationcommunityecosystembiosphere.

  • Example: A human is an organism, made up of organ systems, which are made of organs, and so on down to molecules.

Scientific Process: Hypotheses, Theories, and Experiments

The scientific method is a systematic approach to understanding the natural world.

  • Hypothesis: A testable, falsifiable explanation for an observation.

  • Theory: A broad, well-supported explanation for a wide range of phenomena.

  • Controlled Experiment: An experiment in which only one variable is changed at a time.

  • Variables: Independent variable (manipulated), dependent variable (measured), controlled variables (kept constant).

  • Observational Data/Experiments: Data collected without manipulation, often used in field studies.

Elements, Atoms, and Compounds

All matter is composed of elements, which combine to form compounds essential for life.

  • Element: A substance that cannot be broken down into simpler substances by chemical means.

  • Atom: The smallest unit of an element, consisting of protons, neutrons, and electrons.

  • Atomic Number: Number of protons in an atom.

  • Mass Number: Number of protons plus neutrons.

  • Isotopes: Atoms of the same element with different numbers of neutrons; some are radioactive.

  • Trace Elements: Elements required in very small amounts but essential for life (e.g., iron, iodine).

Chemical Bonds

Atoms combine through chemical bonds to form molecules and compounds.

  • Ionic Bond: Formed when electrons are transferred from one atom to another, resulting in oppositely charged ions.

  • Covalent Bond: Formed when two atoms share one or more pairs of electrons.

  • How to Draw: Use Lewis dot structures to represent valence electrons and bonding.

  • Unique Features: Ionic bonds create charged ions; covalent bonds create stable molecules.

Water: Properties and Importance

Water is essential for life due to its unique chemical and physical properties.

  • Polarity: Water is a polar molecule, with partial positive and negative charges.

  • Hydrogen Bonding: Weak bonds between the hydrogen of one water molecule and the oxygen of another.

  • Cohesion and Adhesion: Cohesion is the attraction between water molecules; adhesion is attraction to other substances.

  • Surface Tension: The result of cohesion at the surface of water.

  • High Specific Heat and Evaporative Cooling: Water resists temperature change and cools surfaces as it evaporates.

  • Solvent Properties: Water dissolves many substances, making it the "universal solvent." Equation:

Acids, Bases, and pH

Acids and bases are substances that alter the hydrogen ion concentration in solutions.

  • Acid: Substance that increases the concentration of H+ ions in solution.

  • Base: Substance that decreases the concentration of H+ ions (or increases OH-).

  • pH Scale: Measures hydrogen ion concentration; ranges from 0 (acidic) to 14 (basic), with 7 as neutral.

  • Equation:

  • Buffers: Substances that minimize changes in pH.

Organic Molecules and Functional Groups

Organic molecules are carbon-based and form the basis of life. Functional groups determine their properties.

  • Hydrocarbons: Molecules consisting only of carbon and hydrogen.

  • Functional Groups: Specific groups of atoms that confer characteristic properties (e.g., -OH, -COOH, -NH2, -PO42-).

  • Isomers: Molecules with the same formula but different structures.

Macromolecules: Carbohydrates, Lipids, Proteins

Macromolecules are large, complex molecules essential for life. They are built from smaller subunits.

Carbohydrates

  • Monosaccharides: Simple sugars (e.g., glucose, fructose).

  • Disaccharides: Two monosaccharides joined by a glycosidic bond (e.g., sucrose).

  • Polysaccharides: Long chains of monosaccharides (e.g., starch, glycogen, cellulose).

  • Function: Energy storage and structural support.

  • Dehydration Reaction: Joins monomers by removing water.

  • Hydrolysis: Breaks polymers into monomers by adding water.

Lipids

  • General Characteristics: Hydrophobic molecules, including fats, phospholipids, and steroids.

  • Fats: Composed of glycerol and fatty acids; used for energy storage.

  • Saturated vs. Unsaturated Fatty Acids: Saturated have no double bonds; unsaturated have one or more double bonds.

  • Steroids: Lipids with a four-ring structure (e.g., cholesterol).

  • Phospholipids: Major component of cell membranes; have hydrophilic heads and hydrophobic tails.

Proteins

  • General Characteristics: Polymers of amino acids; perform a wide range of functions.

  • Amino Acid Structure: Central carbon, amino group (-NH2), carboxyl group (-COOH), hydrogen, and R group.

  • Peptide Bonds: Link amino acids to form polypeptides.

  • Levels of Structure: Primary (sequence), secondary (alpha helix, beta sheet), tertiary (3D folding), quaternary (multiple polypeptides).

  • Denaturation: Loss of protein structure and function due to environmental changes.

Table: Comparison of Macromolecules

Macromolecule

Monomer

Bond Type

Main Functions

Carbohydrates

Monosaccharide

Glycosidic bond

Energy storage, structure

Lipids

Glycerol & Fatty acids

Ester bond

Energy storage, membranes, signaling

Proteins

Amino acid

Peptide bond

Catalysis, structure, transport, signaling

Additional info:

  • Be able to identify macromolecules by their structure and know their general functions.

  • Review the differences between polar and nonpolar covalent bonds, and the significance of hydrophobic vs. hydrophilic molecules.

  • Practice drawing and interpreting basic chemical structures and reactions.

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