교과서 질문
A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.
What does this suggest about the cause of spina bifida?
494
views
Ch. 19 - Epigenetics
Klug12th EditionConcepts of Genetics ISBN: 9780135564776
Not the one you use?Change textbookSelect a different textbook
Table of contents
- Ch. 1 - Introduction to Genetics17
- Ch. 2 - Mitosis and Meiosis36
- Ch. 3 - Mendelian Genetics51
- Ch. 4 - Extensions of Mendelian Genetics74
- Ch. 5 - Chromosome Mapping in Eukaryotes51
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages46
- Ch. 7 - Sex Determination and Sex Chromosomes33
- Ch. 8 - Chromosome Mutations: Variation in Number and Arrangement40
- Ch. 9 - Extranuclear Inheritance31
- Ch. 10 - DNA Structure and Analysis43
- Ch. 11 - DNA Replication and Recombination44
- Ch. 12 - DNA Organization in Chromosomes30
- Ch. 13 - The Genetic Code and Transcription54
- Ch. 14 - Translation and Proteins47
- Ch. 15 - Gene Mutation, DNA Repair, and Transposition41
- Ch. 16 - Regulation of Gene Expression in Bacteria29
- Ch. 17 - Transcriptional Regulation in Eukaryotes41
- Ch. 18 - Post-transcriptional Regulation in Eukaryotes33
- Ch. 19 - Epigenetics33
- Ch. 20 - Recombinant DNA Technology44
- Ch. 21 - Genomic Analysis36
- Ch. 22 - Applications of Genetic Engineering and Biotechnology36
- Ch. 23 - Developmental Genetics37
- Ch. 24 - Cancer Genetics34
- Ch. 25 - Quantitative Genetics and Multifactorial Traits54
- Ch. 26 - Population and Evolutionary Genetics45
19장, 문제 19b
A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.
Does this exclude genetic mutations as a cause of this condition?
검증된 단계별 안내1
Understand the context: Spina bifida is a neural tube defect influenced by both environmental factors (e.g., maternal diet low in folate) and genetic factors. The question asks whether genetic mutations can also contribute to this condition.
Clarify the role of folate: Folate is crucial for DNA synthesis and repair during early development. A deficiency in folate can disrupt normal neural tube closure, increasing the risk of spina bifida. However, this does not rule out genetic contributions.
Explore genetic factors: Genetic mutations in genes involved in folate metabolism (e.g., MTHFR gene) or neural tube development (e.g., VANGL1, SHROOM3) can predispose individuals to spina bifida, even in the presence of adequate folate levels.
Consider gene-environment interactions: Spina bifida is often the result of complex interactions between genetic predispositions and environmental factors, such as maternal folate levels. Both components can play a role in the condition's development.
Conclude: While a maternal diet low in folate is a significant risk factor, it does not exclude genetic mutations as a cause of spina bifida. Both genetic and environmental factors contribute to the condition, and their interplay is critical in understanding its etiology.
비슷한 문제에 대한 검증된 영상 답변:
이 영상 해법은 위 문제에 도움이 된다고 튜터들이 추천한 것입니다.
영상 길이:
1m도움이 되었나요?
주요 개념
질문에 올바르게 답하기 위해 반드시 이해해야 하는 핵심 개념들은 다음과 같습니다.
Neural Tube Defects
Neural tube defects (NTDs) are serious birth defects that occur when the neural tube, which forms the brain and spinal cord, does not close completely during early fetal development. Spina bifida is one of the most common NTDs, characterized by incomplete closure of the spinal column, leading to varying degrees of disability. Understanding NTDs is crucial for recognizing the multifactorial nature of conditions like spina bifida.
추천 영상:
가이드 코스
07:10
Other Gene Interactions
Folate and Its Role in Development
Folate, a B-vitamin, is essential for DNA synthesis and repair, as well as cell division, making it particularly important during pregnancy. A maternal diet low in folate has been linked to an increased risk of NTDs, including spina bifida. This highlights the significance of nutritional factors in fetal development and the prevention of certain congenital disorders.
추천 영상:
가이드 코스
08:30Genetics of Development
Genetic Mutations and Multifactorial Disorders
Genetic mutations can contribute to the risk of developing conditions like spina bifida, but they are often part of a multifactorial model where both genetic and environmental factors interact. While a low folate diet is a significant risk factor, it does not exclude the possibility that genetic predispositions may also play a role in the occurrence of spina bifida, indicating the complexity of its etiology.
추천 영상:
가이드 코스
10:48Mutations and Phenotypes
관련 실천
교과서 질문
How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the accumulation of genetic mutations in tumor-suppressor genes and proto-oncogenes?
562
views
교과서 질문
A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.
Should researchers be looking for mutant alleles of genes that control formation and differentiation of the neural tube?
453
views
교과서 질문
How are mutations in histone acetylation (HAT) genes linked to cancer?
609
views
교과서 질문
Trace the relationship between the methylation status of the glucocorticoid receptor gene and the behavioral response to stress.
676
views
교과서 질문
Prader–Willi syndrome (PWS) is a genetic disorder with a clinical profile of obesity, intellectual disability, and short stature. It can be caused in several ways. Most common is a deletion on the paternal copy of chromosome 15, but it can also be caused by an epigenetic imprinting disorder and uniparental disomy, an event in which the affected child receives two copies of the maternal chromosome 15. A child with PWS comes to your clinic for a diagnosis of the molecular basis for this condition. The gel below shows the results of testing with short tandem repeats (STRs) from the region of chromosome 15 associated with the disorder.
Is this case caused by a deletion in the paternal copy of chromosome 15? Explain.
1276
views