Ch. 15 - Recombinant DNA Technology and Its Applications

Sanders - Genetic Analysis: An Integrated Approach 3rd Edition

Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172당신이 사용하는 게 아니라요?교과서 변경

Sanders 3rd Edition

Ch. 15 - Recombinant DNA Technology and Its Applications

문제 E.7a

15장, 문제 E.7a

The results shown are from a DNA test for four genes used in a paternity identification case. DNA for the mother (M) and her child (C) are shown along with DNA from two possible fathers, F1 and F2. In the 'C' column, label the DNA bands contributed by the mother with 'M' and the DNA bands contributed by the father with 'F.'

검증된 단계별 안내

Step 1: Understand that a child inherits one allele (DNA band) from the mother and one allele from the father for each gene. Therefore, for each gene, the child's DNA bands should be a combination of one band from the mother and one band from the father.

Step 2: For each gene, compare the child's DNA bands with the mother's bands. Identify which band(s) in the child match the mother's bands. Label these matching bands in the child's column as 'M' to indicate maternal contribution.

Step 3: After labeling the maternal bands, the remaining band(s) in the child's DNA for each gene must have come from the father. Label these remaining bands as 'F' to indicate paternal contribution.

Step 4: Repeat this process for all four genes, ensuring that for each gene, one band is labeled 'M' and the other 'F' in the child's DNA column.

Step 5: Use the labeled paternal bands in the child's DNA to compare with the DNA bands of the two possible fathers (F1 and F2) to help identify which father contributed those bands.

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주요 개념

질문에 올바르게 답하기 위해 반드시 이해해야 하는 핵심 개념들은 다음과 같습니다.

Mendelian Inheritance and Allele Contribution

Each individual inherits one allele of a gene from each parent. In paternity testing, the child's DNA bands must match one allele from the mother and one from the father. Identifying which bands come from the mother helps isolate the paternal contribution.

DNA Banding Patterns in Gel Electrophoresis

DNA fragments are separated by size using gel electrophoresis, producing distinct bands. Comparing band patterns between individuals reveals shared alleles. Bands present in the child but absent in the mother indicate paternal origin.

Paternity Testing Using Genetic Markers

Paternity tests analyze multiple genetic loci to determine biological relationships. Matching the child's paternal bands with those of potential fathers helps identify the true father. Consistency across several genes strengthens the accuracy of the test.

관련 실천

교과서 질문

The results shown are from a DNA test for four genes used in a paternity identification case. DNA for the mother (M) and her child (C) are shown along with DNA from two possible fathers, F1 and F2. Based on the exclusion principle, is either man excluded as the possible father? Explain.

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교과서 질문

Using animal models of human diseases can lead to insights into the cellular and genetic bases of the diseases. Duchenne muscular dystrophy (DMD) is the consequence of an X-linked recessive allele.

How would you make a mouse model of DMD?

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교과서 질문

The results shown are from a DNA test for four genes used in a paternity identification case. DNA for the mother (M) and her child (C) are shown along with DNA from two possible fathers, F1 and F2. What can you conclude based on the DNA results available?

440

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교과서 질문

A victim of murder is found to have scrapings containing skin cells under several of her fingernails. Genetic analysis confirms that the DNA isolated from these cells came from the same individual and does not match the DNA of the victim. The results shown below are for six CODIS STR markers from the crime scene DNA (from under the victim's fingernails and presumed to be the murderer's), and from three suspects (A, B, and C) who have been detained for questioning about the murder. Is there a failure to exclude any of the suspects? Explain.

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교과서 질문

Using animal models of human diseases can lead to insights into the cellular and genetic bases of the diseases. Duchenne muscular dystrophy (DMD) is the consequence of an X-linked recessive allele.

How would you make a Drosophila model of DMD?

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교과서 질문

Compare methods for constructing homologous recombinant transgenic mice and yeast.

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