The diagram of a eukaryotic ribosome shown below contains several errors.

Redraw the diagram, and correct each error using the mRNA sequence shown.

If you were to look up Gaucher disease on the OMIM website, you would see that there are three major types, designated Type I (OMIM 230800), Type II (OMIM 230900), and Type III (OMIM 231000). All three types are mutations of the gene for acid-β-glucosidase, encoded on chromosome 1. Different mutations of this gene produce the three types of Gaucher disease that differ somewhat in their symptoms and disease severity.

For each mutation, speculate about whether the acid-β-glucosidase enzyme is merely reduced in function or whether its production is eliminated, and explain why.

If you were to look up Gaucher disease on the OMIM website, you would see that there are three major types, designated Type I (OMIM 230800), Type II (OMIM 230900), and Type III (OMIM 231000). All three types are mutations of the gene for acid-β-glucosidase, encoded on chromosome 1. Different mutations of this gene produce the three types of Gaucher disease that differ somewhat in their symptoms and disease severity.

Thinking about the production or function of the acid-β-glucosidase enzyme, why do you suppose different mutations of this gene produce differences in symptoms and disease severity?

Third-base wobble allows some tRNAs to recognize more than one mRNA codon. Based on this chapter's discussion of wobble, what is the minimal number of tRNA molecules necessary to recognize the following amino acids?

Arginine

The diagram of a eukaryotic ribosome shown below contains several errors.

Examine the diagram carefully, and identify each error.

Third-base wobble allows some tRNAs to recognize more than one mRNA codon. Based on this chapter's discussion of wobble, what is the minimal number of tRNA molecules necessary to recognize the following amino acids?

Isoleucine

Third-base wobble allows some tRNAs to recognize more than one mRNA codon. Based on this chapter's discussion of wobble, what is the minimal number of tRNA molecules necessary to recognize the following amino acids?

Leucine