The immunoglobulin class that mediates type I hypersensitivity is:
a. IgA
b. IgM
c. IgG
d. IgD
e. IgE

검증된 단계별 안내

Understand that type I hypersensitivity reactions are immediate allergic reactions mediated by a specific class of immunoglobulin.

Recall the functions of different immunoglobulin classes: IgA is mainly found in mucosal areas, IgM is the first antibody produced in an immune response, IgG is the most abundant antibody in serum, IgD is primarily a receptor on B cells, and IgE is involved in allergic responses.

Identify that type I hypersensitivity involves the binding of an allergen to IgE antibodies attached to mast cells and basophils, leading to the release of histamine and other mediators.

Conclude that the immunoglobulin class responsible for mediating type I hypersensitivity is IgE.

Match the correct answer choice to IgE, which is option e.

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주요 개념

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Type I Hypersensitivity

Type I hypersensitivity is an immediate allergic reaction triggered by allergens, leading to symptoms like itching, swelling, and anaphylaxis. It involves the activation of mast cells and basophils through antibody binding, causing the release of histamine and other mediators.

Immunoglobulin E (IgE)

IgE is a class of antibodies primarily involved in allergic responses and defense against parasitic infections. It binds to allergens and triggers mast cell degranulation, which releases histamine and other chemicals responsible for type I hypersensitivity symptoms.

Other Immunoglobulin Classes

Immunoglobulins like IgA, IgM, IgG, and IgD have distinct roles: IgA protects mucosal surfaces, IgM is the first antibody in immune responses, IgG provides long-term immunity, and IgD functions mainly as a B cell receptor. None of these mediate type I hypersensitivity.

The immunoglobulin class that mediates type I hypersensitivity is:a. IgAb. IgMc. IgGd. IgDe. IgE