Which combination of clinical signs would most strongly suggest chronic insufficient protein intake?

Generalized edema, recurrent infections, delayed wound healing, and muscle wasting due to loss of structural and immune proteins

Improved lean mass retention while subcutaneous fat increases markedly, because protein deficiency preferentially shunts energy into adipose depots

Hyperactivity, excessive hair growth, and sudden improvements in wound healing because low protein triggers compensatory overproduction of growth factors

Increased bone density, hypertension from excessive oncotic pressure, and reduced infection rates due to increased mobilization of immune resources