Which property distinguishes peptide/protein hormones like insulin from steroid hormones in terms of receptor location and signaling mechanism?

Protein hormones are primarily structural proteins repurposed for signaling, while steroids are made of amino acids similar to proteins and use identical receptors

Protein hormones always cross the cell membrane and bind directly to DNA to change gene expression within seconds, whereas steroids act only on surface enzymes

Protein hormones are typically water-soluble and bind to membrane receptors to trigger intracellular signaling cascades, whereas steroid hormones are lipid-soluble and often bind intracellular receptors that modify gene transcription

Protein hormones are stored as triglycerides in adipose tissue and released on demand while steroid hormones circulate bound to albumin and act by immediate enzyme inhibition