7. Substitution Reactions

Which of the following alkyl halides is most likely to undergo an $S_{N2}$ reaction rapidly?

Given the following alkyl halides: 1. $\mathrm{CH}{3}_{\mathrm{Br}}$ (methyl bromide), 2. $\mathrm{CH}{3}_{\mathrm{CH}}{2}_{\mathrm{Br}}$ (ethyl bromide), 3. $\left(\mathrm{CH}{3}_2\right)\mathrm{CHBr}$ (isopropyl bromide), 4. $\left(\mathrm{CH}{3}_3\right)\mathrm{CBr}$ (tert-butyl bromide), rank them from most to least reactive in an $S{N}_2$ reaction.

Which of the following is the major organic product formed when ${\mathrm{CH}}_3{\mathrm{CH}}_2{\mathrm{Br}}_1$ reacts with ${\mathrm{OH}}_1-$ in an $S{N}_2$ reaction?

Examine the two $S{N}_2$ reactions below: (A) ${\mathrm{CH}}_3\mathrm{Br}$ with $\mathrm{OH}-$ and (B) ${\mathrm{CH}}_3{\mathrm{CH}}_2\mathrm{Br}$ with $\mathrm{OH}-$. Which reaction will proceed at a faster rate?

Which energy diagram best represents an $S{N}_2$ reaction?

Which of the following best represents the transition state for the following SN2 reaction: $\mathrm{CH}{3}_0-$ attacking $\mathrm{CH}{3}_1\mathrm{Br}$?

Which of the following statements best describes the mechanism of an $S_{N2}$ reaction?

Arrange the following compounds in order from fastest to slowest $S_{\mathrm{N}}2$ reaction rate when reacting with ${\mathrm{Br}}_{-}$ as the nucleophile: 1-bromopropane, 2-bromopropane, 2-bromo-2-methylpropane.

Given the following reaction: ${\mathrm{CH}}_3\mathrm{Br}$ + $\mathrm{OH}-$ → ?, predict the major product of this $S{N}_2$ reaction.

Select the single best answer. Which $S{\mathrm{N}}_2$ reaction in the following pair is faster? (A) $\mathrm{CH}{3}_2\mathrm{CHBr}$ with $\mathrm{OH}-$ or (B) $\mathrm{CH}{3}_3\mathrm{CBr}$ with $\mathrm{OH}-$

Which of the following is a property of the $S_{\mathrm{N}}2$ reaction mechanism?

Which of the following pairs of substrates will undergo an $S{N}_2$ reaction faster: (A) ${\mathrm{CH}}_3\mathrm{Br}$ vs. ${\mathrm{CH}}_3{\mathrm{CH}}_2\mathrm{Br}$, (B) ${\mathrm{CH}}_3{\mathrm{CH}}_2\mathrm{Br}$ vs. ${\mathrm{(CH}}_3{)}_2\mathrm{CHBr}$, (C) ${\mathrm{(CH}}_3{)}_2\mathrm{CHBr}$ vs. ${\mathrm{(CH}}_3{)}_3\mathrm{CBr}$?

Which of the following best represents the product of an $S{N}_2$ reaction between ${\mathrm{CH}}_3{\mathrm{CH}}_2{\mathrm{Br}}_1$ (bromoethane) and $\mathrm{OH}-$ (hydroxide ion)?

Which SN2 reaction in the following pair is faster: (A) $\mathrm{CH}{3}_2\mathrm{CHBr}$ with $\mathrm{OH}-$ or (B) $\mathrm{CH}{3}_3\mathrm{CBr}$ with $\mathrm{OH}-$?