The prefix 'mono-' in the term 'monoclonal antibody' most directly indicates which of the following?

You need to ensure genuine monoclonality and production of an antibody with the desired specificity. Which combined screening strategy best guarantees selection of a single hybridoma clone producing the correct monoclonal antibody?

Considering modern antibody production techniques, which evaluation best compares hybridoma-based monoclonal antibody production to recombinant antibody expression systems when prioritizing rapid humanization and large-scale clinical manufacture?