Microbiology
What is the principal molecular action of quinolones and fluoroquinolones on bacterial DNA replication?
How do rifamycins like rifampin inhibit bacterial RNA synthesis?
A 45-year-old man presents with flank pain and a febrile urinary tract infection caused by a ciprofloxacin-susceptible Escherichia coli. Which rationale best supports selecting ciprofloxacin for outpatient therapy in this case?
A laboratory isolate of bacteria shows reduced susceptibility to ciprofloxacin. Sequencing reveals a point mutation in the gyrA gene. Which interpretation best links the genotype to the phenotype?
