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Ch. 33 - Viruses
Freeman - Biological Science 7th Edition
Freeman7th EditionBiological ScienceISBN: 9783584863285Not the one you use?Change textbook
Chapter 33, Problem 6

Compare and contrast the bacteriophage lytic cycle and lysogeny by addressing (1) the rate of replication of the viral genome, (2) production of virions, and (3) effect on the host cell.

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Identify the two different life cycles of bacteriophages: the lytic cycle and the lysogenic cycle. Understand that the lytic cycle involves the destruction of the host cell, while the lysogenic cycle integrates the phage genome into the host cell's genome.
Examine the rate of replication of the viral genome in both cycles. In the lytic cycle, the viral genome replicates rapidly and independently of the host's DNA. In contrast, during lysogeny, the viral genome (now termed a prophage) is replicated passively along with the host's genome during cell division.
Analyze the production of virions, which are complete virus particles. In the lytic cycle, new virions are produced in large quantities, leading to cell lysis and release of the virions. In the lysogenic cycle, virions are not produced until the prophage reactivates to enter the lytic cycle.
Discuss the effect on the host cell in both cycles. The lytic cycle results in the destruction of the host cell through lysis. In the lysogenic cycle, the host cell remains alive and continues to function, often with no detrimental effects until potential induction into the lytic cycle.
Summarize the key differences: the lytic cycle is characterized by rapid viral genome replication, high virion production, and destructive effects on the host cell. The lysogenic cycle involves slower, coordinated replication with the host genome, no immediate virion production, and preservation of the host cell's integrity.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Bacteriophage Lytic Cycle

The lytic cycle is a viral replication process where a bacteriophage infects a host bacterium, hijacks its cellular machinery to replicate its genome, and ultimately causes the host cell to lyse, releasing new virions. This cycle is characterized by rapid replication and high virion production, leading to immediate destruction of the host cell.
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Lysogeny

Lysogeny is a viral replication strategy where the bacteriophage integrates its genome into the host's DNA, remaining dormant as a prophage. This process allows for slower replication rates and no immediate production of virions, as the viral genome is replicated alongside the host's during cell division, potentially leading to future lytic cycles under certain conditions.
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Impact on Host Cell

The impact on the host cell differs significantly between the lytic cycle and lysogeny. In the lytic cycle, the host cell is destroyed as it releases new virions, while in lysogeny, the host cell remains alive and can continue to divide, carrying the viral genome without immediate harm. This difference influences the survival and evolutionary strategies of both the virus and the host.
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