Question 1

Which of the following is NOT a component of a nucleotide?

Accepted Answer

Carboxylic acid group

Question 2

What is the main structural difference between DNA and RNA?

Accepted Answer

DNA is usually double-stranded, while RNA is usually single-stranded

Question 3

Which amino acid is most likely to be found in the DNA-binding pocket of a protein interacting with DNA?

Accepted Answer

Lysine

Question 4

Which of the following best describes the directionality of a polynucleotide chain?

Accepted Answer

It is written from the 5' phosphate end to the 3' OH end

Question 5

Which of the following represents a possible composition of double-stranded DNA according to Chargaff’s rules?

Accepted Answer

15% A, 35% G, 35% C, 15% T

Question 6

What is the reverse complement for the following DNA sequence: 5' TTT CAG GTG CAT 3'?

Accepted Answer

ATG CAC CTG AAA

Question 7

Which cofactor does NOT contain a nucleotide?

Accepted Answer

TPP

Question 8

What is the main stabilizing force for the double-helix structure of DNA?

Accepted Answer

Dispersion forces between stacked aromatic bases

Question 9

Which base pairs with guanine in DNA?

Accepted Answer

Cytosine

Question 10

What is the abbreviation for a nucleotide containing deoxyribose, three phosphates, and thymine?

Accepted Answer

dTTP

Question 11

Which DNA structure is the most compact?

Accepted Answer

Chromosome

Question 12

Which amino acid, in addition to Arg and Lys, would you expect to find in high amounts on DNA-binding histone proteins?

Accepted Answer

His

Question 13

A single ds DNA is replicated to produce 2 DNA double helices. The new nucleic acid contains a label while the original DNA does not. Which statement below is correct?

Accepted Answer

Only one of the ds DNA products contains labeled nucleic acid.

Question 14

Which of the following is a correct description of semiconservative DNA replication?

Accepted Answer

Each new double helix contains one old strand and one new strand.

Question 15

Which of the following is a function of nucleotides in the cell?

Accepted Answer

All of the above

Question 16

Which of the following statements about nucleosides is correct?

Accepted Answer

Nucleosides contain only a sugar and a base.

Question 17

Which of the following is true about the hydrogen bonding in DNA base pairs?

Accepted Answer

A-T pairs form 2 hydrogen bonds and G-C pairs form 3 hydrogen bonds.

Question 18

Which of the following best describes the Central Dogma of molecular biology?

Accepted Answer

DNA is replicated into DNA, transcribed into RNA, and translated into protein.

Question 19

A mutation in DNA caused by a mutagen is propagated during replication. Which of the following is a possible outcome?

Accepted Answer

The mutation can be passed on to daughter cells if not repaired.

Nucleic Acid Structure: DNA, RNA, and Their Biological Functions

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