During a prolonged fast, both glucagon and cortisol levels increase. A physiology student is asked to describe the relationship between these two hormones in maintaining blood glucose levels. Which statement best explains their interaction?

• A. Cortisol decreases hepatic glucose production, opposing the action of glucagon.
• B. Cortisol enhances gluconeogenic enzyme activity, supporting glucagon-induced increases in blood glucose.
• C. Cortisol stimulates insulin release, which counteracts glucagon activity in the liver.
• D. Cortisol blocks glycogen breakdown in hepatocytes, reducing glucagon effectiveness.

Answer: (B)