During a prolonged fast, both glucagon and cortisol levels increase. A physiology student is asked to describe the relationship between these two hormones in maintaining blood glucose levels. Which statement best explains their interaction?

Cortisol decreases hepatic glucose production, opposing the action of glucagon.

Cortisol enhances gluconeogenic enzyme activity, supporting glucagon-induced increases in blood glucose.

Cortisol stimulates insulin release, which counteracts glucagon activity in the liver.

Cortisol blocks glycogen breakdown in hepatocytes, reducing glucagon effectiveness.