Which option correctly compares the mechanisms of action of thyroid hormone and insulin at the cellular level?

Thyroid hormone primarily alters transcription after binding intracellular receptors, whereas insulin activates membrane receptor signaling pathways.

Thyroid hormone acts through cAMP second messengers, whereas insulin directly binds DNA regulatory regions.

Thyroid hormone and insulin both enter the nucleus and directly regulate transcription.

Thyroid hormone binds only surface receptors, whereas insulin diffuses through the plasma membrane to cytoplasmic receptors.