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Competing endogenous RNAs act as molecular 'sponges.' What does this mean, and what do they compete with?
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Ch. 18 - Post-transcriptional Regulation in Eukaryotes
Klug12th EditionConcepts of GeneticsISBN: 9780135564776
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TOC.tableOfContents
- Ch. 1 - Introduction to Genetics17
- Ch. 2 - Mitosis and Meiosis36
- Ch. 3 - Mendelian Genetics51
- Ch. 4 - Extensions of Mendelian Genetics74
- Ch. 5 - Chromosome Mapping in Eukaryotes51
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages46
- Ch. 7 - Sex Determination and Sex Chromosomes33
- Ch. 8 - Chromosome Mutations: Variation in Number and Arrangement40
- Ch. 9 - Extranuclear Inheritance31
- Ch. 10 - DNA Structure and Analysis43
- Ch. 11 - DNA Replication and Recombination44
- Ch. 12 - DNA Organization in Chromosomes30
- Ch. 13 - The Genetic Code and Transcription54
- Ch. 14 - Translation and Proteins47
- Ch. 15 - Gene Mutation, DNA Repair, and Transposition41
- Ch. 16 - Regulation of Gene Expression in Bacteria29
- Ch. 17 - Transcriptional Regulation in Eukaryotes41
- Ch. 18 - Post-transcriptional Regulation in Eukaryotes33
- Ch. 19 - Epigenetics33
- Ch. 20 - Recombinant DNA Technology44
- Ch. 21 - Genomic Analysis36
- Ch. 22 - Applications of Genetic Engineering and Biotechnology36
- Ch. 23 - Developmental Genetics37
- Ch. 24 - Cancer Genetics34
- Ch. 25 - Quantitative Genetics and Multifactorial Traits54
- Ch. 26 - Population and Evolutionary Genetics45
Klug12th EditionConcepts of GeneticsISBN: 9780135564776Non è quello che usi tu?Cambia libro di testo
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Klug 12th EditionCh. 18 - Post-transcriptional Regulation in EukaryotesProblema 18
Klug 12th EditionCh. 18 - Post-transcriptional Regulation in EukaryotesProblema 18Capitolo 18, Problema 18
How are mRNAs stored within the cell in a translationally inactive state, and how can their translation be stimulated?
Guida verificata passo dopo passo1
Understand that mRNAs can be stored in the cell in a translationally inactive state by being sequestered into specific cytoplasmic structures called processing bodies (P-bodies) or stress granules, where translation is temporarily repressed.
Recognize that in these storage sites, mRNAs are often bound by RNA-binding proteins and associated with factors that prevent the assembly of the translation initiation complex, thus keeping them inactive.
Learn that translation can be stimulated by signaling pathways that modify these RNA-binding proteins or translation factors, leading to the release of mRNAs from P-bodies or stress granules.
Know that once released, the mRNAs can recruit the translation initiation machinery, including the eukaryotic initiation factors (eIFs), to form the initiation complex and begin protein synthesis.
Appreciate that this regulation allows the cell to rapidly respond to environmental or developmental cues by controlling when and where specific proteins are produced from stored mRNAs.
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mRNA Storage in Ribonucleoprotein Granules
mRNAs can be stored in the cytoplasm within ribonucleoprotein (RNP) granules such as stress granules and processing bodies (P-bodies). These granules sequester mRNAs in a translationally inactive state, preventing their translation until conditions favor protein synthesis.
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08:39
mRNA Processing
Translational Repression Mechanisms
Translational repression involves proteins and microRNAs binding to mRNAs to inhibit ribosome assembly or progression. This regulation ensures that mRNAs remain untranslated until specific signals relieve repression, allowing controlled protein production.
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07:58Translation initiation
Activation of Translation via Signaling Pathways
Translation can be stimulated by cellular signals that modify translation initiation factors or release mRNAs from inhibitory complexes. For example, phosphorylation events can activate initiation factors, promoting ribosome recruitment and initiating protein synthesis from stored mRNAs.
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04:30Post Translational Modifications
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