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Competing endogenous RNAs act as molecular 'sponges.' What does this mean, and what do they compete with?
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Ch. 18 - Post-transcriptional Regulation in Eukaryotes
Klug12th EditionConcepts of GeneticsISBN: 9780135564776
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TOC.tableOfContents
- Ch. 1 - Introduction to Genetics17
- Ch. 2 - Mitosis and Meiosis36
- Ch. 3 - Mendelian Genetics51
- Ch. 4 - Extensions of Mendelian Genetics74
- Ch. 5 - Chromosome Mapping in Eukaryotes51
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages46
- Ch. 7 - Sex Determination and Sex Chromosomes33
- Ch. 8 - Chromosome Mutations: Variation in Number and Arrangement40
- Ch. 9 - Extranuclear Inheritance31
- Ch. 10 - DNA Structure and Analysis43
- Ch. 11 - DNA Replication and Recombination44
- Ch. 12 - DNA Organization in Chromosomes30
- Ch. 13 - The Genetic Code and Transcription54
- Ch. 14 - Translation and Proteins47
- Ch. 15 - Gene Mutation, DNA Repair, and Transposition41
- Ch. 16 - Regulation of Gene Expression in Bacteria29
- Ch. 17 - Transcriptional Regulation in Eukaryotes41
- Ch. 18 - Post-transcriptional Regulation in Eukaryotes33
- Ch. 19 - Epigenetics33
- Ch. 20 - Recombinant DNA Technology44
- Ch. 21 - Genomic Analysis36
- Ch. 22 - Applications of Genetic Engineering and Biotechnology36
- Ch. 23 - Developmental Genetics37
- Ch. 24 - Cancer Genetics34
- Ch. 25 - Quantitative Genetics and Multifactorial Traits54
- Ch. 26 - Population and Evolutionary Genetics45
Klug12th EditionConcepts of GeneticsISBN: 9780135564776Non è quello che usi tu?Cambia libro di testo
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Klug 12th EditionCh. 18 - Post-transcriptional Regulation in EukaryotesProblema 15
Klug 12th EditionCh. 18 - Post-transcriptional Regulation in EukaryotesProblema 15Capitolo 18, Problema 15
In principle, RNAi may be used to fight viral infection. How might this work?
Guida verificata passo dopo passo1
Understand that RNA interference (RNAi) is a natural cellular process where small RNA molecules inhibit gene expression by degrading specific messenger RNA (mRNA) molecules or blocking their translation.
Recognize that viruses rely on their RNA or DNA to produce viral proteins inside host cells, which are essential for viral replication and infection.
Consider that RNAi can be designed to target viral RNA sequences specifically, leading to the degradation of viral mRNA and preventing the production of viral proteins.
Realize that by introducing small interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs) complementary to viral RNA, the RNA-induced silencing complex (RISC) can be guided to the viral RNA to silence it.
Conclude that this targeted degradation of viral RNA reduces viral replication and spread, thereby helping to fight viral infection through the RNAi mechanism.
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RNA Interference (RNAi) Mechanism
RNAi is a cellular process where small RNA molecules, such as siRNA or miRNA, guide the degradation or translational repression of complementary messenger RNA (mRNA). This mechanism effectively silences specific genes by preventing their expression, which can be harnessed to target viral RNA.
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Percorso guidato
06:59
RNA Interference
Viral RNA Targeting
Viruses often rely on RNA genomes or produce RNA transcripts during infection. RNAi can be designed to specifically recognize and bind to viral RNA sequences, leading to their degradation and thus inhibiting viral replication within host cells.
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Therapeutic Application of RNAi
Using RNAi as an antiviral strategy involves delivering synthetic or vector-expressed small RNAs into infected cells to trigger RNAi against viral genes. This approach offers a targeted method to reduce viral load and combat infections without affecting host genes.
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04:15Artificial Selection
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RNAi may be directed by small interfering RNAs (siRNAs) or microRNAs (miRNAs); how are these similar, and how are they different?
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miRNAs target endogenous mRNAs in a sequence-specific manner. Explain, conceptually, how one might identify potential mRNA targets for a given miRNA if you only know the sequence of the miRNA and the sequence of all mRNAs in a cell or tissue of interest.
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Present an overview of RNA interference (RNAi). How does the silencing process begin, and what major components participate?
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Domanda del libro di testo
How are mRNAs stored within the cell in a translationally inactive state, and how can their translation be stimulated?
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While circular RNAs were first described long ago, they have only recently been investigated for function. What are their known and suspected functions in the cell?
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