Domanda del libro di testo
An experiment by Khorana and his colleagues translated a synthetic mRNA containing repeats of the trinucelotide UUG.
How many reading frames are possible in this mRNA?
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Ch. 9 - The Molecular Biology of Translation
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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TOC.tableOfContents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Non è quello che usi tu?Cambia libro di testo
Capitolo 9, Problema 24c
Har Gobind Khorana and his colleagues performed numerous experiments translating synthetic mRNAs. In one experiment, an mRNA molecule with a repeating UG dinucleotide sequence was assembled and translated.
How did the polypeptide composition help confirm the triplet nature of the genetic code?
Guida verificata passo dopo passo1
Understand the context: Har Gobind Khorana's experiments involved synthesizing mRNA molecules with specific repeating sequences to study how codons are translated into amino acids. The repeating UG dinucleotide sequence in this experiment is key to understanding the triplet nature of the genetic code.
Recognize the repeating UG sequence: The mRNA molecule consists of a repeating UG dinucleotide sequence, which can be represented as UGUGUGUG... This sequence is read by the ribosome in sets of three nucleotides (triplets) during translation.
Determine the possible codons: From the repeating UG sequence, the ribosome can form two distinct codons depending on the reading frame: UGU and GUG. These codons correspond to specific amino acids based on the genetic code.
Analyze the polypeptide composition: Translation of the mRNA results in a polypeptide composed of alternating amino acids, which correspond to the codons UGU and GUG. This alternating pattern confirms that the genetic code is read in triplets, as the sequence produces distinct amino acids depending on the reading frame.
Conclude the significance: The experiment demonstrated that the genetic code operates in a triplet manner, as the repeating UG sequence produced a predictable and consistent polypeptide composition based on the codons formed. This provided strong evidence for the triplet nature of the genetic code.
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Triplet Nature of the Genetic Code
The genetic code is composed of codons, which are sequences of three nucleotides that correspond to specific amino acids. This triplet nature means that each set of three nucleotides in mRNA translates into one amino acid during protein synthesis. Understanding this concept is crucial for interpreting how sequences of nucleotides dictate the structure and function of proteins.
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11:43
The Genetic Code
Synthetic mRNA and Translation
Synthetic mRNA is artificially created RNA that can be used in experiments to study translation and protein synthesis. By using a repeating sequence, such as UG, researchers can predict the resulting polypeptide chain. The translation of synthetic mRNA into proteins provides direct evidence of how codons are read and interpreted by the ribosome.
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07:58Translation initiation
Polypeptide Composition and Codon Analysis
The composition of the resulting polypeptide from the translation of synthetic mRNA can reveal the specific amino acids produced, which in turn confirms the triplet nature of the genetic code. By analyzing the sequence of amino acids, scientists can deduce how many nucleotides correspond to each amino acid, thereby supporting the hypothesis that three nucleotides form a single codon.
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02:48Chi Square Analysis
Pratica correlata
Domanda del libro di testo
The amino acid sequence of a portion of a polypeptide is
N...Cys-Pro-Ala-Met-Gly-His-Lys...C
Give the DNA template and coding strand sequences corresponding to the mRNA. Use the N, Pu, and Py symbols as placeholders.
714
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Domanda del libro di testo
Har Gobind Khorana and his colleagues performed numerous experiments translating synthetic mRNAs. In one experiment, an mRNA molecule with a repeating UG dinucleotide sequence was assembled and translated.
If the genetic code were overlapping rather than nonoverlapping, how would the result of this experiment be different?
759
views
Domanda del libro di testo
Har Gobind Khorana and his colleagues performed numerous experiments translating synthetic mRNAs. In one experiment, an mRNA molecule with a repeating UG dinucleotide sequence was assembled and translated.
Write the sequence of this mRNA and give its polarity.
642
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Domanda del libro di testo
Har Gobind Khorana and his colleagues performed numerous experiments translating synthetic mRNAs. In one experiment, an mRNA molecule with a repeating UG dinucleotide sequence was assembled and translated.
If the genetic code were a doublet code instead of a triplet code, how would the result of this experiment be different?
627
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Domanda del libro di testo
Har Gobind Khorana and his colleagues performed numerous experiments translating synthetic mRNAs. In one experiment, an mRNA molecule with a repeating UG dinucleotide sequence was assembled and translated.
What is the sequence of the resulting polypeptide?
582
views