Skip to main content
Ch.10 Proteins Workers of the Cell
Frost - General, Organic and Biological Chemistry 4th Edition
Frost4th EditionGeneral, Organic and Biological ChemistryISBN: 9780134988696당신이 사용하는 게 아니라요?교과서 변경
모든 교과서Frost 4th EditionCh.10 Proteins Workers of the Cell문제 92b
6장, 문제 92b

A substrate is held in the active site of an enzyme by attractive forces between the substrate and the amino acid side chains. For the outlined regions A, B, and C on the following substrate molecule:
Diagram showing a substrate molecule with labeled regions A, B, and C, illustrating enzyme-substrate interactions.
b. Could the amino acids serine, lysine, or glutamate be present in the active site? Support your answer.

검증된 단계별 안내
1
Step 1: Understand the problem by identifying the substrate regions (A, B, and C) and the amino acids mentioned (serine, lysine, and glutamate). Recognize that the question is asking whether these amino acids could interact with the substrate in the enzyme's active site.
Step 2: Recall the chemical properties of the amino acids: Serine has a polar hydroxyl (-OH) group, lysine has a positively charged amine group (-NH3+), and glutamate has a negatively charged carboxylate group (-COO-). These properties determine the types of interactions they can form.
Step 3: Consider the types of attractive forces that can occur between the substrate and the amino acid side chains. These include hydrogen bonding, ionic interactions, and dipole-dipole interactions. Match the substrate's functional groups in regions A, B, and C with the amino acid side chains based on their chemical compatibility.
Step 4: Analyze each region of the substrate molecule (A, B, and C) to determine the functional groups present. For example, if region A contains a hydroxyl group, it could form hydrogen bonds with serine. If region B contains a negatively charged group, it could interact with lysine via ionic attraction. If region C contains a positively charged group, it could interact with glutamate via ionic attraction.
Step 5: Conclude whether serine, lysine, or glutamate could be present in the active site based on the compatibility of their side chains with the substrate's functional groups in regions A, B, and C. Support your answer by explaining the specific interactions that would occur.

비슷한 문제에 대한 검증된 영상 답변:

이 영상 해법은 위 문제에 도움이 된다고 튜터들이 추천한 것입니다.
영상 길이:
3m
도움이 되었나요?

주요 개념

질문에 올바르게 답하기 위해 반드시 이해해야 하는 핵심 개념들은 다음과 같습니다.

Enzyme-Substrate Interaction

Enzymes are biological catalysts that speed up chemical reactions by binding to substrates at their active sites. The interaction between an enzyme and its substrate is primarily driven by non-covalent forces such as hydrogen bonds, ionic interactions, and hydrophobic effects. Understanding this interaction is crucial for determining how specific amino acids in the active site can influence substrate binding.
추천 영상:
가이드 코스
2:32
Enzyme-Substrate Complex Concept 1

Amino Acid Properties

Amino acids have distinct side chains that determine their chemical properties, such as polarity, charge, and size. For instance, serine is polar and can form hydrogen bonds, lysine is positively charged at physiological pH, and glutamate is negatively charged. These properties influence how these amino acids interact with substrates and other molecules in the active site of an enzyme.
추천 영상:
가이드 코스
3:03
Amino Acid Catabolism: Amino Group Example 2

Active Site Specificity

The active site of an enzyme is specifically shaped to accommodate its substrate, allowing for precise interactions. The presence of certain amino acids in the active site can enhance or inhibit substrate binding based on their chemical properties. Evaluating whether serine, lysine, or glutamate could be present in the active site requires analyzing how their characteristics align with the substrate's structure and the nature of the interactions involved.
추천 영상:
가이드 코스
01:37
Specific Gravity
관련 실천
교과서 질문

What type of interactions between an enzyme and its substrate help to stabilize ES?

726
views
교과서 질문

If each of the following amino acid side chains is present in the active site of an enzyme, indicate whether it would (a) serve a catalytic function, (b) serve to hold the substrate, or (c) both.

d. lysine

648
views
교과서 질문

If each of the following amino acid side chains is present in the active site of an enzyme, indicate whether it would (a) serve a catalytic function, (b) serve to hold the substrate, or (c) both.

a. aspartate

492
views
교과서 질문

Pepsin, an enzyme that hydrolyzes peptide bonds in proteins, functions in the stomach at a pH optimum of 1.5 to 2.0. How is the rate of a pepsin-catalyzed reaction affected by each of the following conditions?

a. increasing the concentration of proteins

977
views
교과서 질문

Does each of the following statements describe a simple enzyme (no cofactor or coenzyme necessary), an enzyme that requires a cofactor, or an enzyme that requires a coenzyme?

c. contains vitamin B6 in its active site

1034
views
교과서 질문

Does each of the following statements describe a simple enzyme (no cofactor or coenzyme necessary), an enzyme that requires a cofactor, or an enzyme that requires a coenzyme?

b. consists of one polypeptide chain in its active form

844
views