A patient with congenital absence of leptin-producing adipocytes is trying to regulate appetite. Which combined behavioral and dietary plan best compensates for absent leptin signaling to reduce long-term hyperphagia?

Implement a structured program emphasizing higher-protein, higher-fiber meals at regular intervals, portion control with external cues, and increased physical activity to enhance peripheral satiety signals and reduce reliance on adiposity-derived leptin.

Prescribe a very-low-fat ketogenic diet without attention to portion size, because absolute elimination of dietary fat fully replaces leptin's regulatory roles over time.

Encourage unrestricted access to energy-dense snacks but increase meal frequency to every 30 minutes in order to prevent ghrelin from rising appreciably, as constant feeding mimics normal leptin feedback.

Recommend periodic fasting for multiple days each week while avoiding any protein intake to allow endogenous gut hormones to fully compensate by elevating CCK and suppressing appetite chronically.