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Antimicrobial Resistance
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Antimicrobial Resistance
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28. Antimicrobial Drugs / Antimicrobial Resistance / Problem 4
Problem 4
Which mechanism is best illustrated by production of beta-lactamase enzymes by bacteria?
A
Enzymatic inactivation — the enzyme chemically breaks down the antibiotic (e.g., cleaving the beta-lactam ring).
B
Rapid efflux — beta-lactamase functions as a membrane pump that expels antibiotics from the cytoplasm.
C
Target alteration — beta-lactamase methylates ribosomes to prevent binding of beta-lactams.
D
Decreased influx — beta-lactamase reduces antibiotic entry through porins into gram-negative bacteria.
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