During glycolysis, ATP acts as an inhibitor for phosphofructokinase when the energy charge in the cell is high. What describes this process?

• A. ATP competes with ADP at phosphofructokinase's active site, preventing further glycolysis
• B. ATP binds to an allosteric site on phosphofructokinase, causing a shape change that lowers the affinity for fructose-6-phosphate
• C. Phosphofructokinase increases catalytic efficiency in response to elevated ATP concentrations, promoting more rapid glycolysis
• D. ATP triggers proteolytic cleavage of phosphofructokinase, rendering it inactive

Answer: (B)