Isoniazid's primary bactericidal activity against Mycobacterium tuberculosis is due to inhibition of which biosynthetic pathway?

• A. DNA gyrase-mediated supercoiling during replication by directly intercalating into DNA and preventing enzyme binding.
• B. Mycolic acid synthesis in the mycobacterial cell wall.
• C. Peptidoglycan transpeptidation via direct binding to penicillin-binding proteins.
• D. Protein synthesis at the 50S ribosomal subunit inhibiting translocation of the nascent polypeptide chain.

Answer: (B)