Infants receive maternal antibodies that can blunt responses to some vaccines. Which synthesized strategy best mitigates maternal antibody interference while still protecting neonates from severe disease?

• A. Administer live attenuated vaccines immediately at birth because maternal antibodies always enhance replication of attenuated strains and thereby increase immunogenicity in neonates
• B. Delay live attenuated vaccines until maternal antibodies wane and use passive maternal immunization during pregnancy or early neonatal administration of inactivated/subunit vaccines with higher antigen dose or adjuvants as interim protection
• C. Rely solely on community herd immunity and avoid vaccinating neonates or mothers because indirect protection removes the need to consider maternal antibody effects
• D. Use variolation techniques in neonates to expose them early to lesion material which historically generated faster immunity than modern vaccines and is unaffected by maternal antibodies

Answer: (B)