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Which of the following definitions is correct?
A prophylactic monoclonal IgG infusion produces an initial serum concentration of 200 units of neutralizing activity. The protected threshold is 25 units. If the monoclonal IgG has an effective clinical half-life in the patient of 21 days, after how many days will the neutralizing activity decline to the threshold level? Show calculations.
Why does passive transfer of antibodies not lead to the recipient producing antigen-specific memory B cells?
A child is bitten by a potentially rabid animal. The clinician gives immediate human rabies immunoglobulin and begins a multi-dose rabies vaccine series. According to decision rules, what types of acquired immunity are provided by the immunoglobulin and the vaccine respectively?
During an outbreak of a novel pathogen, public health officials must choose between mass prophylactic monoclonal antibody distribution for immediate protection and a time-consuming vaccine campaign aimed at long-term immunity. Which evaluation best summarizes trade-offs to inform policy?