$$\text{Immunogenicity} \propto \text{Antigen Size}$$

Question 1

Which of the following is NOT one of the five attributes of adaptive immunity?

Accepted Answer

Non-specificity

Question 2

A patient receives a vaccine containing a protein antigen. Which property of the antigen makes it most likely to stimulate a strong immune response?

Accepted Answer

It is a protein with structural complexity

Question 3

Which organ is the site of maturation for T lymphocytes?

Accepted Answer

Thymus

Question 4

Which class of MHC protein is found on all nucleated cells except red blood cells?

Accepted Answer

MHC class I

Question 5

A virus infects a cell and produces viral proteins inside the cell. Which type of antigen is this and which MHC class will present it?

Accepted Answer

Endogenous antigen, presented by MHC class I

Question 6

Which process ensures that T cells do NOT attack normal body cells?

Accepted Answer

Clonal deletion

Question 7

Which of the following best describes the role of helper T cells in the activation of cytotoxic T cells?

Accepted Answer

They provide growth factors and regulate cytotoxic T cell activation

Question 8

During a secondary exposure to a pathogen, the adaptive immune response is faster due to which attribute?

Accepted Answer

Memory

Question 9

Which of the following is a function of regulatory T cells?

Accepted Answer

Suppress autoimmune responses

Question 10

Which equation best represents the relationship between antigen size and immunogenicity?

Accepted Answer

$$	ext{Immunogenicity} \propto 	ext{Antigen Size}$$

Question 11

A dendritic cell migrates to a lymph node and presents an antigen to a T cell. What is the next step in the activation of cytotoxic T cells?

Accepted Answer

Helper T cell differentiation

Question 12

Which pathway involves the use of perforin and granzyme to kill infected cells?

Accepted Answer

Perforin-granzyme pathway

Question 13

Which of the following is TRUE about B lymphocytes?

Accepted Answer

They are responsible for humoral immunity

Question 14

Which equation describes the clonal expansion of T cells after activation?

Accepted Answer

$$N = N_0$ 	imes 2^n$$

Question 15

Which of the following is a secondary lymphoid organ?

Accepted Answer

Lymph node

Question 16

Which statement best explains why autoantigens do not normally trigger an immune response?

Accepted Answer

T cells that recognize autoantigens are deleted during maturation

Question 17

Which of the following is the correct sequence for activation of cytotoxic T cells?

Accepted Answer

Antigen presentation → Helper T cell differentiation → Clonal expansion → Self-stimulation

Question 18

A patient with a genetic defect in MHC class I proteins would have difficulty with which immune function?

Accepted Answer

Presenting endogenous antigens to cytotoxic T cells

Question 19

Which of the following best describes the role of memory T cells?

Accepted Answer

They respond rapidly to previously encountered antigens without the need for antigen-presenting cells

Question 20

Which equation best represents the exponential increase in T cell numbers during clonal expansion?

Accepted Answer

$$N = N_0$ 	imes 2^n$$

Adaptive Immunity: Structure, Function, and Mechanisms (Chapter 16 Study Notes)

Study Guide - Practice Questions