Antimicrobial Treatment: Principles, Mechanisms, and Resistance

{"type":"doc","content":[{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Antimicrobial Treatment"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Principles of Antimicrobial Therapy"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Antimicrobial chemotherapy aims to administer drugs that destroy infectious agents without harming the host. While the ideal drug does not exist, several characteristics define an effective antimicrobial agent."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Toxic to the microbe but nontoxic to the host:"},{"type":"text","text":" Selectively targets microbial cells."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Microbicidal rather than microbiostatic:"},{"type":"text","text":" Kills microbes instead of merely inhibiting their growth."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Soluble in body fluids:"},{"type":"text","text":" Ensures effective distribution throughout the body."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Remains potent long enough to act:"},{"type":"text","text":" Not rapidly broken down or excreted."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Slow development of resistance:"},{"type":"text","text":" Reduces the likelihood of treatment failure."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Assists host defenses:"},{"type":"text","text":" Complements immune system activity."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Active in tissues and fluids:"},{"type":"text","text":" Maintains efficacy in various body environments."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Readily delivered to infection site:"},{"type":"text","text":" Achieves therapeutic concentrations where needed."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Does not disrupt host health:"},{"type":"text","text":" Minimizes allergies and secondary infections."}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Example:"},{"type":"text","text":" Penicillins are highly selective for bacterial cell walls, which are absent in human cells."}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Terminology of Antimicrobials"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Prophylaxis:"},{"type":"text","text":" Use of drugs to prevent imminent infection in at-risk individuals."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Antimicrobials:"},{"type":"text","text":" General term for drugs targeting any microorganism."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Antibiotics:"},{"type":"text","text":" Substances (natural or synthetic) that inhibit or destroy bacteria."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Semisynthetic drugs:"},{"type":"text","text":" Natural compounds chemically modified in the lab (e.g., modified penicillins)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Synthetic drugs:"},{"type":"text","text":" Entirely lab-produced compounds."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Narrow-spectrum:"},{"type":"text","text":" Effective against a limited range of microbes (e.g., only gram-positive bacteria)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Broad-spectrum:"},{"type":"text","text":" Effective against a wide variety of microbes (e.g., both gram-positive and gram-negative bacteria)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Origins of Antimicrobial Drugs"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Semisynthetic drugs:"},{"type":"text","text":" Modified to improve efficacy and resistance to inactivation (e.g., penicillins with altered side chains)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Synthetic drugs:"},{"type":"text","text":" Designed to target specific bacterial structures, though many struggle to penetrate bacterial membranes."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Starting Antimicrobial Treatment"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Before initiating therapy, three factors must be considered:"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Identity of the infecting microorganism"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Microorganism's susceptibility to drugs"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Patient's overall medical condition"}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Identification should occur before drug administration, using direct examination of body fluids or specimens."}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Testing for Drug Susceptibility"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Kirby–Bauer Technique:"},{"type":"text","text":" Discs with antibiotics are placed on a bacterial lawn to assess susceptibility."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Minimum Inhibitory Concentration (MIC):"},{"type":"text","text":" The smallest drug dose that inhibits microbial growth."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Therapeutic Index (TI):"},{"type":"text","text":" Ratio of toxic dose to effective dose. Higher TI indicates greater safety."}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"inlineMath","attrs":{"latex":" \\text{Therapeutic Index (TI)} = \\frac{\\text{Toxic Dose}}{\\text{Effective Dose}} "}}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Therapeutic window:"},{"type":"text","text":" Range of drug concentration in blood that is effective without being toxic."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Selective Toxicity"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Selective toxicity is the central concept in antimicrobial therapy. Drugs should target microbial cells without harming host tissues. The best drugs block synthesis or function of molecules unique to microbes."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Example:"},{"type":"text","text":" Penicillins inhibit bacterial cell wall synthesis, a structure absent in human cells."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Suppression and Alteration of Human Microbiota"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Antimicrobials can disrupt normal microbiota, leading to overgrowth of opportunistic pathogens (superinfections)."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Examples:"},{"type":"text","text":" Vaginal yeast infection ("},{"type":"text","marks":[{"type":"italic"}],"text":"Candida albicans"},{"type":"text","text":"), antibiotic-associated colitis ("},{"type":"text","marks":[{"type":"italic"}],"text":"Clostridioides difficile"},{"type":"text","text":")."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Mechanisms of Drug Action on Microbes"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Metabolic Targets of Chemotherapeutic Agents"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Inhibition of cell wall synthesis"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Inhibition of nucleic acid (DNA/RNA) structure and function"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Inhibition of protein synthesis (ribosomes)"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Interference with cell membrane structure/function"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Inhibition of folic acid synthesis"}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Antibacterial Drugs Targeting the Cell Wall"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"β-Lactams:"},{"type":"text","text":" Large group including penicillins and cephalosporins."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Penicillins:"},{"type":"text","text":" Three-part structure (thiazolidine ring, β-lactam ring, variable side chain)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Cephalosporins:"},{"type":"text","text":" Isolated from "},{"type":"text","marks":[{"type":"italic"}],"text":"Cephalosporium acremonium"},{"type":"text","text":", similar to penicillins."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Carbapenems:"},{"type":"text","text":" Reserved for multidrug-resistant infections."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Other drugs:"},{"type":"text","text":" Bacitracin, isoniazid, vancomycin."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Antibacterial Drugs Targeting Protein Synthesis"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Act on bacterial ribosomes to inhibit protein synthesis (e.g., tetracyclines)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Antibacterial Drugs Targeting Folic Acid Synthesis"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Sulfa drugs (Sulfonamides):"},{"type":"text","text":" Inhibit folic acid synthesis, essential for nucleotide production."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Examples:"},{"type":"text","text":" Sulfisoxazole (UTIs), silver sulfadiazine (burns), trimethoprim (often combined with sulfamethoxazole)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Antibacterial Drugs and Biofilms"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Bacteria in biofilms are up to 1,000 times less sensitive to antimicrobials than free-living cells."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Biofilm bacteria express different phenotypes, complicating treatment."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Treatment strategies:"},{"type":"text","text":" Interrupt quorum-sensing, use daptomycin, or pretreat to disrupt biofilm structure."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Fungal and Viral Infections"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Fungi:"},{"type":"text","text":" Eukaryotic cells similar to humans, making selective toxicity difficult. Many antifungals are also toxic to human cells."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Viruses:"},{"type":"text","text":" Antiviral agents act by preventing viral entry, blocking replication/transcription/translation, or preventing maturation of viral particles."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Antimicrobial Resistance"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Acquisition of Drug Resistance"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Drug resistance:"},{"type":"text","text":" Microbes adapt to tolerate drugs that would normally inhibit them."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Intrinsic resistance:"},{"type":"text","text":" Natural resistance (e.g., bacteria resistant to their own antibiotics)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Acquired resistance:"},{"type":"text","text":" Resistance developed after exposure to drugs."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"How Resistance Arises"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Spontaneous mutation:"},{"type":"text","text":" Random mutations may confer resistance; rare but possible in large populations."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Horizontal gene transfer:"},{"type":"text","text":" Resistance genes (R factors) transferred via conjugation, transformation, or transduction. Transposons can move resistance genes between plasmids and chromosomes."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Mechanisms of Drug Resistance"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"New enzymes inactivate the drug (often via acquired genes)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Decreased permeability or uptake of the drug (often via mutation)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Drug is actively pumped out of the cell (efflux pumps)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Natural Selection and Drug Resistance"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Resistant cells survive drug exposure and proliferate, leading to a population shift toward resistance."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Human Role in Antimicrobial Resistance"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Overprescription, especially for viral infections, accelerates resistance."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Hospital environments and animal feeds (80% of US antibiotics used in livestock) contribute to resistance spread."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"New Approaches to Antimicrobial 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(Selected)"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Four characteristics of an ideal antimicrobial drug:"},{"type":"text","text":" Toxic to microbe, microbicidal, soluble in body fluids, slow resistance development."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Kirby-Bauer test:"},{"type":"text","text":" Disk diffusion method for antimicrobial susceptibility."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Therapeutic index:"},{"type":"text","text":" Higher TI means less toxicity."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Superinfection:"},{"type":"text","text":" Overgrowth of opportunistic pathogens after antimicrobial therapy."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Antifungal/antihelminthic drugs:"},{"type":"text","text":" Can be toxic to human cells due to eukaryotic similarities."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Antiviral drugs:"},{"type":"text","text":" Fewer in number compared to antibiotics."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Majority of antibiotics in US:"},{"type":"text","text":" Used in livestock."}]}]}]},{"type":"paragraph","attrs":{"textAlign":null}},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"data:image/png;base64,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