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Comprehensive Study Notes: Foundations of Microbiology

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Introduction to Microbiology

  • Discovering Microorganisms
    03:36
  • Introduction to Microbiology
    07:27
  • Introduction to Microbiology Channel
    1:29

Acellular Infectious Agents: Viruses, Viroids & Prions

  • Viruses
    03:22
  • Prions
    02:48
  • Acellular Infectious Agents: Viruses, Viroids & Prions
    02:54

Members of the Bacterial World

  • Members of the Bacterial World
    06:17

Introduction to Bacteria

  • Introduction to Bacteria
    06:18

Introduction to Archaea

  • Introduction to Archaea
    04:39

Introduction to Eukarya

  • Helminths
    01:27
  • Fungi
    02:49
  • Introduction to Eukarya
    03:28

Introduction to Spontaneous Generation

  • Biogenesis vs. Spontaneous Generation
    02:05
  • Introduction to Spontaneous Generation
    05:59

Koch's Postulates

  • Koch's Postulates
    01:36
  • The 4 Koch's Postulates
    03:31
  • Limitations to Koch's Postulates
    02:58

Bacterial Cell Morphology & Arrangements

  • Types of Bacterial Cell Morphology
    02:44
  • Bacterial Cell Morphology & Arrangements
    01:13
  • Bacilli Bacterial Cell Arrangements
    03:56

Overview of Prokaryotic Cell Structure

  • Overview of Prokaryotic Cell Structure
    05:59

Introduction to Bacterial Cell Walls

  • Peptidoglycan
    01:58
  • Types of Bacterial Cell Walls
    02:44
  • Peptidoglycan Structure
    04:44

Gram-Positive Cell Walls

  • Teichoic Acids
    03:58
  • Gram-Positive Cell Walls
    02:59

Gram-Negative Cell Walls

  • Gram-Negative Cell Walls
    3:04
  • Porins
    02:18
  • The Outer Membrane
    02:15

Gram-Positive vs. Gram-Negative Cell Walls

  • Mnemonic for Gram-Positive vs. Gram-Negative Cell Walls
    01:41
  • Gram-Positive vs. Gram-Negative Cell Walls
    04:46

Introduction to Bacterial Plasmids

  • Episomes
    01:47
  • Introduction to Bacterial Plasmids
    02:52

Introduction to Bacteria

  • Introduction to Bacteria
    06:18

Binary Fission

  • Binary Fission
    02:16
  • Steps of Binary Fission
    04:57

Generation Times

  • Calculating Generation Times
    05:48
  • Generation Times
    02:54

Introduction to Microbial Genetics

  • Map of the Lesson on Microbial Genetics
    02:04
  • Introduction to Microbial Genetics
    04:20

Introduction to Mutations

  • Spontaneous vs. Induced Mutations
    02:47
  • Introduction to Mutations
    00:37
  • Types of Mutations
    08:44

The Ames Test

  • The Ames Test
    06:59

Introduction to DNA Replication

  • Unwinding the DNA:Topoisomerase, Helicase & SSBs
    05:10
  • Components of DNA Replication
    04:47
  • Origin of Replication
    03:33

Central Dogma

  • Central Dogma
    05:45

Introduction to Transcription

  • Overview of Transcription
    07:44
  • Introduction to Transcription
    05:51

Introduction to Translation

  • Ribosomal tRNA Binding Sites
    06:16
  • Ribosome Subunits
    08:42
  • Introduction to Translation
    06:12

Prokaryotic Gene Regulation via Operons

  • Inducible Operons
    04:25
  • Prokaryotic Gene Regulation via Operons
    00:53
  • Repressible Operons
    03:42

The Lac Operon

  • In the Absence of Lactose
    04:34
  • The Lac Operon
    07:06
  • In the Presence of Lactose
    03:56

Glucose's Impact on Lac Operon

  • Positive Control by cAMP & CRP
    08:32
  • Glucose's Impact on Lac Operon Example 1
    06:20
  • Glucose Levels, cAMP, & the Lac Operon
    05:58

The Trp Operon

  • In the Presence of Tryptophan
    03:11
  • The Trp Operon
    05:30
  • In the Absence of Tryptophan
    03:42

Review of the Lac Operon & Trp Operon

  • Review of the Lac Operon & Trp Operon
    06:24

Horizontal Gene Transfer

  • Fates of Horizontally Transferred DNA
    03:13
  • Horizontal Gene Transfer
    04:42
  • Integration of DNA via Homologous Recombination
    02:52

Bacterial Transformation

  • Bacterial Transformation
    03:06
  • Mechanism of Natural Transformation
    03:49

Transduction

  • Generalized Transduction
    04:24
  • Transduction
    06:49
  • Specialized Transduction
    06:34

Introduction to Conjugation

  • Introduction to Conjugation
    04:21

CRISPR CAS

  • CRISPR CAS
    07:43

Introduction to Bacteria

  • Introduction to Bacteria
    06:18

Introduction to Energy

  • Thermodynamics: System vs. Surroundings
    04:21
  • Introduction to Energy
    04:58

Redox Reactions

  • Redox Reactions Example 1
    01:44
  • Electron Carriers: NADH & FADH2
    05:22
  • Redox Reactions
    04:46

Enzymes

  • Functions of Enzymes
    02:32
  • Enzymes Example 1
    02:25
  • Enzymes
    02:55

Introduction to Metabolism

  • Introduction to Metabolism
    02:17
  • Catabolic & Anabolic Pathways
    03:25

Introduction to Aerobic Cellular Respiration

  • Stages of Aerobic Cellular Respiration
    02:32
  • Introduction to Aerobic Cellular Respiration
    03:38
  • Introduction to Aerobic Cellular Respiration Example 2
    01:53

Glycolysis

  • Phases of Glycolysis
    05:57
  • Glycolysis Example 1
    01:29
  • Remembering Phases of Glycolysis
    02:49

Krebs Cycle

  • Krebs Cycle Example 1
    01:20
  • Krebs Cycle
    01:37
  • Phases of The Krebs Cycle
    09:54

Electron Transport Chain

  • Remembering the ETC
    04:43
  • Electron Transport Chain in Prokaryotes
    02:49
  • Electron Transport Chain
    07:41

Chemiosmosis

  • Chemiosmosis
    05:01

Fermentation & Anaerobic Respiration

  • Lactic Acid Fermentation
    03:33
  • What Happens to Aerobic Organisms if There's No Oxygen?
    07:50
  • Alcohol Fermentation
    01:59

Introduction to Photosynthesis

  • Introduction to Photosynthesis
    03:32
  • Photosynthesis is a Redox Reaction
    03:20
  • Photosynthesis vs. Cellular Respiration
    07:55

Microbial Growth Curves in a Closed System

  • Microbial Growth Curves in a Closed System
    08:59
  • Primary & Secondary Metabolites
    02:33

Temperature Requirements for Microbial Growth

  • Temperature Requirements for Microbial Growth
    04:16
  • Classification of Microbes by Growth Temperature
    04:56
  • How to Memorize the Classification of Microbes by Growth Temperatures
    01:59

Oxygen Requirements for Microbial Growth

  • Reactive Oxygen Species
    04:43
  • Oxygen Requirement Classes of Microbes
    07:27
  • Oxygen Requirements for Microbial Growth
    03:52

Introduction to Cultivating Microbial Growth

  • Map of Techniques for Cultivating Microbes
    02:05
  • Introduction to Cultivating Microbial Growth
    03:49

Introduction to Controlling Microbial Growth

  • Terminology of Microbial Growth Control
    07:36
  • Hierarchy of Microbial Growth Control Terminology
    03:09
  • Situations Warranting Different Levels of Microbial Growth Control
    05:58

Physical Methods to Control Microbial Growth

  • Dry Heat
    02:58
  • Irradiation
    06:18
  • Filtration
    04:29

Chemical Methods to Control Microbial Growth

  • Types of Disinfectants
    05:21
  • Selecting the Right Chemical Agent
    04:52
  • Chemical Methods to Control Microbial Growth
    03:58

Introduction to Viruses

  • General Structure of Viruses
    04:47
  • Three Common Shapes of Viruses
    03:19
  • Enveloped vs. Non-Enveloped Viruses
    05:09

Introduction to Bacteriophage Infections

  • Map of Lesson on Bacteriophage Infections
    03:52
  • Productive vs. Latent State Infections
    04:09
  • Lytic & Lysogenic Bacteriophages
    04:34

Introduction to Animal Virus Infections

  • Introduction to Animal Virus Infections
    02:33
  • Memorizing the Steps of Animal Virus Infections
    01:40

The Griffith Experiment

  • The Griffith Experiment
    08:56

The Hershey-Chase Experiment

  • The Hershey-Chase Experiment
    03:59
  • Bacteriophages
    03:44

Introduction to Immunity

  • Innate vs. Adaptive Immunity
    05:52
  • Antigens & Antibodies
    02:58

Introduction to Innate Immunity

  • Introduction to Innate Immunity
    02:30
  • Map of Lesson on Innate Immunity
    06:42

Introduction to First-Line Defenses

  • Introduction to First-Line Defenses
    01:51
  • Map of the Lesson on First-Line Defenses
    01:35

Physical Barriers in First-Line Defenses: Skin

  • Physical Barriers in First-Line Defenses: Skin
    01:28
  • Physical Barriers in First-Line Defenses: Skin
    03:58

Physical Barriers in First-Line Defenses: Mucous Membrane

  • Peristalsis & Mucociliary Escalator
    04:14
  • Mucous Membranes
    02:34

First-Line Defenses: Chemical Barriers

  • Chemical Defenses: Gastric Juice Prevents Microbial Growth by Lowering pH
    02:07
  • Chemical Defenses: Earwax Prevents Microbial Growth by Controlling pH
    02:18
  • Chemical Defenses: Sweat Glands Prevent Microbial Growth by Perspiration
    02:04

First-Line Defenses: Normal Microbiota

  • Normal Microbiota
    03:43

Introduction to Cells of the Immune System

  • Introduction to Cells of the Immune System
    03:21
  • Map of the Lesson on Cells of the Immune System
    06:08
  • Hematopoiesis
    02:33

Cells of the Immune System: Granulocytes

  • Granulocytes
    03:32
  • Neutrophils
    05:26
  • Basophils
    03:23

Cells of the Immune System: Agranulocytes

  • Monocytes
    07:16
  • Introduction to Lymphocytes
    03:51
  • Agranulocytes
    03:43

Introduction to the Complement System

  • Map of the Lesson on the Complement System
    03:25
  • Introduction to the Complement System
    04:25
  • Proteins of the Complement System
    04:16

Phagoctytosis

  • Steps of Phagocytosis
    08:57
  • Phagoctytosis
    02:19

Introduction to Inflammation

  • Types of Inflammatory Responses
    02:52
  • Introduction to Inflammation
    01:38
  • Chronic Inflammation
    03:09

Steps of the Inflammatory Response

  • 2) Release of Inflammatory Mediators & Other Cytokines
    02:15
  • Damaging Effects of the Inflammatory Response
    02:10
  • 3) Vasodilation
    02:39

Fever

  • Fever
    03:57

Interferon Response

  • Interferon Response
    01:32
  • Steps of the Interferon Response
    09:59

Introduction to Adaptive Immunity

  • Overview of Adaptive Immunity
    04:57
  • Primary vs. Secondary Lymphoid Organs
    04:58
  • Introduction to Adaptive Immunity
    05:47

Antigens

  • Free Antigens vs. Presented Antigens on APCs
    04:11
  • Antigens
    03:59

Introduction to T Lymphocytes

  • Cytotoxic T Cells vs. Helper T Cells
    05:58
  • T-Cell Receptors
    05:18
  • Naive T Cells Become Effector & Memory T Cells
    07:56

Major Histocompatibility Complex Molecules

  • Classes of MHC Molecules
    07:17
  • Major Histocompatibility Complex Molecules
    02:31

Activation of T Lymphocytes

  • Activation of T Lymphocytes
    07:33
  • Comic Strip for T Cell Activation
    03:29

Functions of T Lymphocytes

  • Functions of Helper T Cells (TH):Activation of Macrophages
    05:18
  • Types of Helper T Cells (TH)
    03:19
  • Functions of Cytotoxic T Cells (Tc)
    06:21

Review of Cytotoxic vs Helper T Cells

  • Review of Cytotoxic vs Helper T Cells
    04:27
  • Comic Strip for T Cell Functions
    02:58

Introduction to B Lymphocytes

  • B cell Receptors
    04:37
  • Naive B cells Become Effector (Plasma) Cells & Memory Cells
    04:23
  • Introduction to B Lymphocytes
    03:55

Antibodies

  • Antibody Structure
    05:40
  • Antibody Diversity
    02:34
  • Antibodies
    00:48

Classes of Antibodies

  • IgE
    02:45
  • IgA
    02:44
  • Classes of Antibodies
    04:43

Outcomes of Antibody Binding to Antigen

  • Outcomes of Antibody Binding to Antigen
    09:16

T Dependent & T Independent Antigens

  • B Cell Activation by T Dependent Antigens
    05:09
  • T Dependent & T Independent Antigens
    02:08
  • B Cell Activation by T Independent Antigens
    03:11

Clonal Selection

  • Clonal Selection
    06:43

Antibody Class Switching

  • Antibody Class Switching
    07:52

Affinity Maturation

  • Affinity Maturation
    07:27

Primary and Secondary Response of Adaptive Immunity

  • Primary and Secondary Response of Adaptive Immunity
    06:59

Immune Tolerance

  • Central vs. Peripheral Tolerance
    11:54
  • Immune Tolerance
    03:19
  • Football Analogy for Immune Tolerance
    03:21

Regulatory T Cells

  • Regulatory T Cells
    03:53

Natural Killer Cells

  • Natural Killer Cells
    06:53

Review of Adaptive Immunity

  • Review of Adaptive Immunity
    09:20

Types of Acquired Immunity

  • Types of Acquired Immunity: Natural vs. Artificial
    02:31
  • 4 Types of Acquired Immunity
    03:52
  • Types of Acquired Immunity: Active vs. Passive
    02:21

Introduction to Vaccines

  • History of Vaccines
    04:19
  • 2 Types of Vaccines
    02:03

Attenuated Vaccines

  • Attenuated Vaccines
    03:06

Inactivated Vaccines

  • Inactivated Vaccines Example 1
    02:12
  • Inactivated Vaccines Example 2
    01:23
  • Review of Attenuated & Inactivated Vaccines
    03:40

Introduction to Antimicrobial Drugs

  • Guided course
    History of Antimicrobial Drugs
    05:33

How Antimicrobial Drugs Work

  • Guided course
    Selective Toxicity
    05:27
  • Guided course
    How Antimicrobial Drugs Work Example 1
    03:28

Broad vs Narrow Spectrum Drugs

  • Guided course
    Broad vs Narrow Spectrum
    04:05

Superinfections

  • Guided course
    Superinfections Example 1
    01:59
  • Guided course
    Superinfections
    05:16

Therapeutic Window & Therapeutic Index

  • Guided course
    Therapeutic Window & Therapeutic Index
    04:08

Inhibitors of Cell Wall Synthesis: Beta-lactam & Penicillin

  • Guided course
    Inhibitors of Cell Wall Synthesis: Beta-lactam & Penicillin Example 3
    04:02
  • Guided course
    Other Beta-lactam Antibiotics
    04:51
  • Inhibitors of Cell Wall Synthesis: Beta-lactam & Penicillin Example 2
    02:21

Inhibitors of Protein Synthesis

  • Guided course
    Inhibitors of Protein Synthesis
    05:25
  • Guided course
    Inhibitors of Protein Synthesis Example 1
    03:04

Disruptors of Cell Membranes

  • Guided course
    Disruptors of Cell Membranes
    04:03

Inhibitors of Nucleic Acid Synthesis

  • Guided course
    Inhibitors of Nucleic Acid Synthesis Example 1
    02:21
  • Guided course
    Inhibitors of Nucleic Acid Synthesis
    05:01

Competitive Inhibitors of Metabolic Pathways

  • Guided course
    Competitive Inhibitors of Metabolic Pathways Example 1
    02:36
  • Guided course
    Sulfa Drugs & Folic Acid Synthesis
    05:22

Antimicrobial Resistance

  • Guided course
    Types of Resistance Mechanisms
    05:04
  • Guided course
    Spread of Antibiotic Resistance
    04:45
  • Guided course
    Antibiotic Resistance
    03:45

Characteristics of Infectious Disease

  • Primary vs. Secondary Infections
    04:16
  • Communicable vs. Noncommunicable Diseases
    04:57
  • Intro to Characteristics of Infectious Disease
    05:09

Stages of Infectious Disease Progression

  • Stages of Infectious Disease Progression
    05:36
  • Chronic & Latent Infection Disease Progression
    05:14

Bacterial Pathogenesis

  • Intro to Bacterial Pathogenesis
    02:35
  • 1) Exposure to Pathogen
    03:27
  • 3) Invasion into Host Tissues
    05:38

Introduction to Pathogenic Toxins

  • Introduction to Pathogenic Toxins
    03:40

Exotoxins Cause Damage to the Host

  • 1) A-B Toxins
    04:44
  • Types of Exotoxins
    03:30
  • 3) Superantigens
    03:59

Endotoxin Causes Damage to the Host

  • Endotoxin
    02:46
  • Lipid A Causes Septic Shock
    03:24

Exotoxins vs. Endotoxin Review

  • Exotoxins vs. Endotoxin Review
    07:22

Immune Response Damage to the Host

  • Inflammatory Response Can damage the Host
    03:31
  • Intro to Immune Response Damage
    02:57
  • Adaptive Immunity Can Damage the Host
    03:22

Introduction to Avoiding Host Defense Mechanisms

  • Introduction to Avoiding Host Defense Mechanisms
    01:59

1) Hide Within Host Cells

  • Hide Within Host Cells
    01:50

2) Avoiding Phagocytosis

  • Pathogen Use Capsules & M Proteins to Avoid Opsonization
    05:25
  • Pathogens Avoid Encounter with Phagocytes
    05:13
  • Pathogens Use Fc Receptors to Prevent Opsonization
    03:48

3) Surviving Inside Phagocytic Cells

  • Surviving Inside Phagocytic Cells
    04:18

4) Avoiding Complement System

  • Avoiding Complement System
    04:53

5) Avoiding Antibodies

  • Bacteria Avoid Antibodies by Producing IgA Proteases
    02:59
  • Bacteria Avoid Immune System by Mimicking Host Molecules
    03:11
  • Intro to Avoiding Antibodies
    01:35

Viruses Evade the Immune Response

  • 3) Viruses Avoid the Effects of Antibodies
    3:57
  • Intro to How Viruses Evade the Immune Response
    02:13
  • 2) Viruses Interfere with Antigen Presentation in Infected Cells
    3:43