Question 1

Which of the following best describes the mechanism of action of glucocorticoids in immunosuppression?

Accepted Answer

They act as anti-inflammatory agents and inhibit T cell activity.

Question 2

A patient receives a kidney transplant and is prescribed cyclosporine. What is the primary immunological effect of this drug?

Accepted Answer

Blocks T cell responses by inhibiting calcineurin.

Question 3

Which immunosuppressive drug class includes cyclophosphamide and azathioprine, and what is their main action?

Accepted Answer

Cytotoxic drugs; block cell division nonspecifically.

Question 4

Which of the following is a lymphocyte-depleting therapy and what is its primary action?

Accepted Answer

Antithymocyte globulin; depletes lymphocytes, or all subsets of T cells, or a subset of T cell receptors.

Question 5

A patient with an autoimmune disease is treated with methotrexate. What is the mechanism of action of this drug?

Accepted Answer

Blocks cell division nonspecifically.

Question 6

Which immunosuppressive drug is most likely to be used to prevent allograft rejection by specifically blocking T cell responses?

Accepted Answer

Cyclosporine

Question 7

Which of the following immunosuppressive agents is most likely to impair both B and T cell responses by blocking DNA replication?

Accepted Answer

Azathioprine

Question 8

A patient is given antithymocyte globulin after a bone marrow transplant. What is the expected effect of this therapy?

Accepted Answer

It depletes lymphocytes, including all or subsets of T cells.

Question 9

Which of the following drugs is a glucocorticoid and what is its primary immunosuppressive action?

Accepted Answer

Prednisone; anti-inflammatory for T cells.

Question 10

Which immunosuppressive drug class is most likely to be used in combination with other agents to prevent organ rejection and acts by blocking T cell responses?

Accepted Answer

Cyclosporine

Immunization, Immune Testing, Hypersensitivities, Autoimmunity, and Immunodeficiency

Study Guide - Practice Questions

Study Guide - Flashcards