Question 1

Which of the following viruses is the only human pathogen with a single-stranded DNA (ssDNA) genome?

Accepted Answer

Parvovirus B19

Question 2

A patient presents with smooth, waxy papules on the face and trunk. The lesions are not painful and the patient is otherwise healthy. Which virus is the most likely cause?

Accepted Answer

Molluscipoxvirus

Question 3

Which of the following factors did NOT contribute to the eradication of smallpox?

Accepted Answer

Asymptomatic carriers spreading the virus

Question 4

A laboratory image shows a cell with a large nucleus containing a dense, basophilic inclusion ('owl's eye' appearance). This is diagnostic for infection with which virus?

Accepted Answer

Cytomegalovirus (HHV-5)

Question 5

Which of the following best describes the genome of Hepatitis B virus (HBV)?

Accepted Answer

Partially double-stranded and partially single-stranded DNA

Question 6

A child develops a highly infectious rash after a mild respiratory illness. Years later, as an adult, the same individual develops a painful, localized rash along a dermatome. Which virus is responsible for both diseases?

Accepted Answer

Human herpesvirus 3 (Varicella-zoster virus)

Question 7

Which of the following is a common route of transmission for adenoviruses causing conjunctivitis?

Accepted Answer

Respiratory droplets

Question 8

Which of the following statements about papillomaviruses is TRUE?

Accepted Answer

They cause benign growths called papillomas (warts)

Question 9

A patient with a compromised immune system develops progressive multifocal leukoencephalopathy (PML). Which virus is most likely responsible?

Accepted Answer

JC virus

Question 10

Which of the following is a unique feature of Hepatitis B virus replication?

Accepted Answer

It replicates through an RNA intermediary

Question 11

A sexually active adult presents with painful genital lesions. Laboratory testing confirms a DNA virus with latency in the sacral ganglia. Which virus is most likely responsible?

Accepted Answer

Human herpesvirus 2 (HHV-2)

Question 12

Which of the following is a major risk factor for the development of liver cancer in patients with chronic hepatitis B infection?

Accepted Answer

Coinfection with hepatitis D virus

Question 13

Which of the following best explains why chickenpox is more severe in adults than in children?

Accepted Answer

Adults have a more robust immune response, leading to more tissue damage

Question 14

Which of the following is a characteristic sign of erythema infectiosum (fifth disease) caused by Parvovirus B19?

Accepted Answer

Reddening of the skin aggravated by sunlight

Question 15

Which of the following is the primary method of transmission for Epstein-Barr virus (HHV-4)?

Accepted Answer

Saliva

Question 16

A patient presents with jaundice, liver enlargement, and abdominal distress. Laboratory tests reveal the presence of viral antigens in the blood. Which virus is most likely responsible?

Accepted Answer

Hepatitis B virus

Question 17

Which of the following is a reason why prevention of most types of warts is difficult?

Accepted Answer

Papillomaviruses are highly resistant to environmental conditions and can be transmitted by fomites

Question 18

Which of the following best describes the pathogenesis of infectious mononucleosis caused by Epstein-Barr virus?

Accepted Answer

The virus infects B lymphocytes and cytotoxic T cells kill infected B cells

Question 19

Which of the following is a common complication of cytomegalovirus (CMV) infection in immunodeficient patients?

Accepted Answer

Severe organ damage and 'owl's eye' inclusions in cells

Question 20

Which of the following viruses is associated with the development of Kaposi’s sarcoma?

Accepted Answer

Human herpesvirus 8 (HHV-8)

Pathogenic DNA Viruses: Structure, Diseases, and Clinical Features

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