The Human Host and Its Microbiome: Infection, Disease, and Pathogenesis

{"type":"doc","content":[{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Section 13.1: The Human Host and Its Microbiome"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Introduction to the Human Microbiome"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"The human body is host to trillions of microorganisms, collectively known as the "},{"type":"text","marks":[{"type":"bold"}],"text":"microbiota"},{"type":"text","text":", which play essential roles in health and disease. The concept of the "},{"type":"text","marks":[{"type":"bold"}],"text":"holobiont"},{"type":"text","text":" refers to a human plus all of its resident microbiota."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Colonization:"},{"type":"text","text":" The presence of established resident microbiota that generally do not cause disease."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Infection:"},{"type":"text","text":" The invasion and multiplication of pathogenic microorganisms in host tissues, overcoming host defenses."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Disease:"},{"type":"text","text":" A pathological state resulting from infection, leading to tissue or organ damage and deviation from health."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"The Human Microbiome Project (HMP)"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Human cells have approximately 21,000 protein-encoding genes, while the microbes inhabiting humans possess 8–20 million genes."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Microbes are present in body sites previously considered sterile."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Healthy individuals harbor both beneficial and potentially pathogenic microbes, including viruses."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"The composition of the microbiome influences susceptibility to viral infections (e.g., influenza, HIV), effectiveness of treatments, and overall health."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Sites Harboring Normal Microbiota"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Definitive sites:"},{"type":"text","text":" Skin, upper respiratory tract, gastrointestinal tract (including mouth), outer urethra, bladder, urine, external genitalia, vagina, external ear canal, external eye (lids and conjunctiva), breast milk."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Additional sites:"},{"type":"text","text":" Lungs (lower respiratory tract), placenta, amniotic fluid, fetus."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Detected by DNA:"},{"type":"text","text":" Brain, bloodstream."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Endogenous Infections"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Caused by normal biota introduced to previously sterile sites."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Example:"},{"type":"text","text":" "},{"type":"text","marks":[{"type":"italic"}],"text":"Streptococcus pneumoniae"},{"type":"text","text":" can cause pneumonia in immunocompromised individuals."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Acquisition of Microbiota"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Evidence suggests colonization may begin in utero."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Exposure occurs during birth (vaginal biota) and through breast milk, which contains bacteria and indigestible sugars that support gut microbiota development."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Section 13.2: The Progress of Infection"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Pathogens and Virulence"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Pathogen:"},{"type":"text","text":" A microbe with a parasitic relationship to its host, causing infection and disease."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"True pathogens:"},{"type":"text","text":" Cause disease in healthy individuals."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Opportunistic pathogens:"},{"type":"text","text":" Cause disease when host defenses are compromised or when present in unusual locations."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Virulence:"},{"type":"text","text":" The degree of pathogenicity, determined by the ability to establish infection and cause damage."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Virulence factors:"},{"type":"text","text":" Microbial characteristics or structures that contribute to pathogenicity (e.g., toxins, enzymes)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Infectious Dose and Polymicrobial Infections"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Infectious dose (ID):"},{"type":"text","text":" The minimum number of microbes required to initiate infection. Lower IDs indicate higher virulence."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Polymicrobial infections:"},{"type":"text","text":" Infections involving multiple microbial species (e.g., influenza virus followed by bacterial pneumonia)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Host Variability and Biosafety Levels"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Host genetics, exposure history, and overall health influence susceptibility to infection."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Biosafety levels (BSL) categorize pathogens based on their risk and handling requirements (as defined by the CDC)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Steps in Establishing Infection"}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Step 1: Portals of Entry"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Microbes enter the host via specific routes: skin, mucous membranes, gastrointestinal tract, respiratory tract, urogenital tract."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Exogenous sources:"},{"type":"text","text":" Originate outside the body (environment, other people, animals)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Endogenous sources:"},{"type":"text","text":" Originate from the host's own microbiota."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Step 2: Adhesion to Host Tissues"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Microbes attach to host cells via specific interactions between microbial adhesins and host receptors."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Attachment is essential for colonization and invasion."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Quorum sensing:"},{"type":"text","text":" Bacterial communication that coordinates group behaviors critical for infection establishment."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Step 3: Surviving Host Defenses"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Phagocytes:"},{"type":"text","text":" White blood cells that engulf and destroy pathogens."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Antiphagocytic factors:"},{"type":"text","text":" Mechanisms used by pathogens to evade or survive phagocytosis (e.g., capsules, survival inside phagocytes)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Epigenetic mechanisms:"},{"type":"text","text":" Pathogens can alter host gene expression without changing DNA sequence, affecting immune responses."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Step 4: Causing Disease"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Virulence factors:"},{"type":"text","text":" Enable pathogens to invade, establish, and damage host tissues."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Three main mechanisms of host damage:"}]},{"type":"orderedList","attrs":{"start":1,"type":null},"content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Direct damage via enzymes:"},{"type":"text","text":" Exoenzymes (e.g., mucinase, keratinase, hyaluronidase) degrade host tissues and barriers."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Toxins:"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Exotoxins:"},{"type":"text","text":" Secreted proteins toxic in small amounts."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Endotoxins:"},{"type":"text","text":" Lipopolysaccharide (LPS) from Gram-negative bacteria, released upon cell death."}]}]}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Inducing excessive host response:"},{"type":"text","text":" Overactive immune responses can cause tissue damage (e.g., long-haul COVID-19 symptoms)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Epigenetic changes:"},{"type":"text","text":" Microbes can modulate host gene expression to their advantage."}]}]}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Acute vs. Chronic Infections"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Acute infections:"},{"type":"text","text":" Rapid onset, short duration."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Chronic infections:"},{"type":"text","text":" Slow progression, long duration."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Signs and Symptoms of Disease"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Sign:"},{"type":"text","text":" Objective evidence observed by others (e.g., fever, rash)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Symptom:"},{"type":"text","text":" Subjective experience reported by the patient (e.g., pain, fatigue)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Syndrome:"},{"type":"text","text":" A set of signs and symptoms characteristic of a disease."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Common Signs"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Fever, septicemia, microbes in tissue fluids, chest sounds, skin eruptions, leukocytosis, leukopenia, swollen lymph nodes, abscesses, tachycardia, antibodies in serum."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Common Symptoms"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Chills, pain, malaise, fatigue, chest tightness, itching, headache, nausea, abdominal cramps, anorexia, sore throat."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Inflammation"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Earliest sign of disease; includes edema (fluid accumulation), granulomas/abscesses (localized collections of immune cells and microbes), lymphadenitis (swollen lymph nodes)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Blood Infections"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Leukocytosis:"},{"type":"text","text":" Increased white blood cells."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Leukopenia:"},{"type":"text","text":" Decreased white blood cells."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Septicemia:"},{"type":"text","text":" Microbes multiplying in blood."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Bacteremia:"},{"type":"text","text":" Bacteria present in blood, not necessarily multiplying."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Viremia:"},{"type":"text","text":" Viruses present in blood."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Asymptomatic Infections"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Infections without noticeable symptoms; host does not seek medical attention."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Step 5: Portals of Exit"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Pathogens exit the host via secretions, excretions, discharges, or sloughed tissue."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"The Course of an Infection"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Incubation period:"},{"type":"text","text":" Time from exposure to first symptoms."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Prodromal period:"},{"type":"text","text":" Early, mild symptoms."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Acute phase:"},{"type":"text","text":" Peak of infection and symptoms."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Convalescent stage:"},{"type":"text","text":" Recovery and decline of symptoms."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Reservoirs and Transmission"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Reservoir:"},{"type":"text","text":" Natural habitat of a pathogen (e.g., humans, animals, soil, water)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Source:"},{"type":"text","text":" Immediate origin from which infection is acquired (may differ from reservoir)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Carrier:"},{"type":"text","text":" Individual harboring and transmitting a pathogen without symptoms."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Vectors"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Biological vector:"},{"type":"text","text":" Animal (often arthropod) that participates in the pathogen's life cycle and transmits it to humans (e.g., mosquito for malaria)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Mechanical vector:"},{"type":"text","text":" Animal that passively carries pathogens without being infected (e.g., flies transferring 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Transmission"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Horizontal transmission:"},{"type":"text","text":" Spread among individuals in a population (direct contact, indirect contact, vectors)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Vertical transmission:"},{"type":"text","text":" Parent to offspring (via ovum, sperm, placenta, or milk)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Koch’s Postulates and Etiology"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Robert Koch developed criteria to establish the causative agent of a disease."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Koch’s postulates remain foundational in infectious disease research."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Sample Table: Comparison of Exotoxins and Endotoxins"}]},{"type":"table","content":[{"type":"tableRow","content":[{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Feature"}]}]},{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Exotoxin"}]}]},{"type":"tableHeader","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Endotoxin"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Source"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Secreted by living 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doses)"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Heat Stability"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Unstable (inactivated at 60°C)"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Stable"}]}]}]},{"type":"tableRow","content":[{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Effect on Host"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Specific (targeted cells/tissues)"}]}]},{"type":"tableCell","attrs":{"colspan":1,"rowspan":1,"colwidth":null},"content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Systemic (fever, shock)"}]}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Key Equations"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Infectious Dose (ID):"}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"inlineMath","attrs":{"latex":"ID_{50} = \\text{Number of microbes required to infect 50\\% of the test population}"}}]},{"type":"paragraph","attrs":{"textAlign":null}},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"data:image/png;base64,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