Which enzymes are responsible for final hydrolysis of dipeptides and tripeptides inside enterocytes?

• A. Gastric lipases and salivary amylases hydrolyze dipeptides and tripeptides to amino acids as they pass through the stomach and mouth.
• B. Pancreatic amylase and pancreatic lipase, secreted into the small intestine, are responsible for cleaving peptide bonds of dipeptides and tripeptides inside enterocytes.
• C. Intestinal nucleases break dipeptides and tripeptides into amino acids and are therefore the primary final digestive enzymes for proteins.
• D. Dipeptidases and tripeptidases located on the brush border and within enterocytes complete hydrolysis to single amino acids.

Answer: (D)