Which medication class lowers blood glucose primarily by increasing insulin secretion from pancreatic β-cells and therefore has a risk of causing hypoglycemia if dosed inappropriately?

• A. Loop diuretics — they stimulate pancreatic α-cells to secrete glucagon and are the primary hypoglycemia-causing diabetes drugs.
• B. Statins — they directly increase GLUT4 expression in muscle and therefore carry the greatest risk of hypoglycemia.
• C. SGLT2 inhibitors (e.g., empagliflozin) — they increase hepatic gluconeogenesis to lower blood glucose and do not affect insulin secretion.
• D. Sulfonylureas (e.g., glipizide) — they stimulate β-cell insulin release and can cause hypoglycemia if dose or meal timing is mismatched.

Answer: (D)