Which of the following therapeutic actions would most directly mimic calcitonin's physiological effects on calcium homeostasis?

• A. An agent that stimulates PTH release and increases renal 1-alpha-hydroxylase activity
• B. A drug that increases urinary calcium excretion and reduces osteoclast-mediated bone resorption
• C. A compound that blocks intestinal vitamin D receptors to heighten calcium absorption
• D. A hormone that enhances osteoclast differentiation and increases bone calcium mobilization

Answer: (B)