Why does alcohol consumption often lead to increased urine production (diuresis) and contribute to hangover symptoms?

• A. Alcohol binds to renal tubule proteins and mechanically blocks urine reabsorption, which is permanent unless treated with diuretics that reverse the blockage.
• B. Alcohol directly increases aldosterone secretion leading to enhanced sodium and water retention, which paradoxically causes increased urine production through compensatory mechanisms.
• C. Alcohol triggers a rise in blood glucose that is filtered and excreted in the urine, and it is this glycosuria rather than water loss that causes classic hangover dehydration.
• D. Alcohol suppresses vasopressin (antidiuretic hormone), reducing water reabsorption in the kidneys which increases urine output and can lead to dehydration and electrolyte losses underlying hangover symptoms.

Answer: (D)