Glucose-6-phosphate must isomerize to fructose-6-phosphate prior to cleavage with aldolase in glycolysis. Why?

• A. Because the carbonyl group must be a ketone in order to accept the electrons resulting from C2-C3 bond cleavage.
• B. Because the carbonyl group must be deprotonated in order to accept the electrons resulting from C1-C2 bond cleavage.
• C. Because the carbonyl group must be in the 2-position in order to accept the electrons resulting from C3-C4 bond cleavage.
• D. None of the above

Answer: (C)