Determine which of the following statements about drug administration routes is true:

• A. Transdermal patches can provide a steady systemic release of a drug over hours to days. 
• B. Oral tablets always produce peak blood levels within 5 minutes. 
• C. Intranasal delivery is generally much less rapid than inhalation (smoking) for reaching the brain.
• D. Rectal administration never exposes a drug to hepatic first-pass metabolism.

Answer: (A)