How does high hydrogen ion concentration in tissues affect hemoglobin protonation and oxygen release?

• A. High hydrogen ion concentration leads to hemoglobin protonation, destabilizing the T state and binding oxygen.
• B. High hydrogen ion concentration leads to hemoglobin decarbonation, stabilizing the R state and binding oxygen.
• C. High hydrogen ion concentration has no effect on hemoglobin protonation or oxygen release.
• D. High hydrogen ion concentration leads to hemoglobin protonation, stabilizing the T state and releasing oxygen.

Answer: (D)