How does the physiological adaptation of increased BPG concentration in individuals with anemia impact oxygen release?

• A. Increased BPG concentration decreases oxygen affinity, reducing oxygen release.
• B. Increased BPG concentration has no impact on oxygen release in anemia.
• C. Increased BPG concentration reduces oxygen release, worsening anemia symptoms.
• D. Increased BPG concentration enhances oxygen release to compensate for low hemoglobin levels.

Answer: (D)