Synthesize the effects of pH changes on hemoglobin's oxygen affinity using Le Chatelier's principle.

• A. Lower pH increases oxygen affinity in tissues, while higher pH decreases it in lungs.
• B. Lower pH decreases oxygen affinity in tissues, while higher pH increases it in lungs.
• C. pH changes have no effect on oxygen affinity.
• D. Lower pH increases oxygen affinity in both tissues and lungs.

Answer: (B)