QTL Mapping Practice Problems

In QTL mapping, how are the sources of DNA for genetic markers identified and how are data for the quantitative trait of interest derived?

The variation in the phenotypic trait can be associated with the quantitative trait locus (QTL). A specific chromosome region may contain a QTL if that region frequently contains:

Horst Wilkens researched blind cavefish in 1988, comparing them to individuals of a sibling species located in a lake with normal eyesight. The species with normal vision were named "lake fish." Speculate on the role of the genes involved in this difference.

Which of the following is a true statement regarding the genetics of blind cavefish?

QTL mapping is based on which of the following principles?

Quantitative trait locus (QTL) mapping is a method to determine the location of:

Brachydactyly is a genetic condition characterized by shortened fingers and toes. Which of the following is a possible genetic mode of inheritance for brachydactyly?

By the BC4 generation in backcrossing, the offspring are ____ genetically similar to the recurrent parent.

In backcrossing, the initial cross between a donor and the recurrent parent can yield an F1 progeny with ____ of their genetic material.

Which of the following statements about the backcross experiment is true?

Which of the following methods is used to determine the gene from the quantitative trait locus?

When the marker locus and the quantitative trait locus consistently cosegregate, it means that:

Which of the following are the chromosome-specific DNA markers that can be used to find and map quantitative trait loci (QTLs)?

What is the purpose of fine mapping in QTL mapping?

What role do single nucleotide polymorphisms play in QTL mapping?

What is the main advantage of using GWAS for studying complex traits compared to traditional linkage mapping?