Enzyme Inhibition Practice Problems

Consider the three forms of enzyme inhibition (competitive, uncompetitive, and irreversible). Determine if the statement below is true or false. If false, correct the statement:

Each of the three kinds of inhibition involves the formation of covalent bonds with the enzyme.

Classify the inhibition described below as uncompetitive, competitive, or irreversible: A certain drug is used to manage a specific viral infection. The drug works by binding to the enzyme in the virus and does not dissociate.

Determine the kind of inhibition (uncompetitive, competitive, or irreversible) present in the following:

A certain pesticide works by attaching itself to an allosteric site on an insect’s digestive enzymes and slowing down their activity without permanently inactivating them.

A reversible type of enzyme inhibition of mercury can be stopped by chelation therapy using DMSA. Describe this type of mercury inhibition.

Identify the type of product that could potentially serve as a competitive inhibitor for the enzyme that facilitates its production.

True or False: A competitive inhibitor can be identified from an uncompetitive inhibitor by increasing the substrate concentration and monitoring the reaction's rate change.

Which type of enzyme inhibitor is often considered poison? Explain your answer.

How does the rate of a biochemical reaction catalyzed by an enzyme change when the concentration of a non-competitive inhibitor is increased, keeping the substrate concentration constant?

How does the rate of a biochemical reaction catalyzed by an enzyme change when the concentration of a non-competitive inhibitor is decreased, keeping the substrate concentration constant?

Identify the type of enzyme regulation in the scenario below:

The conversion of phosphoenolpyruvate to pyruvate, catalyzed by pyruvate kinase, is inhibited by high concentrations of alanine. Note that in this reaction, alanine is neither a product nor a substrate.