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Ch. 16 - Adaptive Immunity
Bauman - Microbiology with Diseases by Taxonomy 6th Edition
Bauman6th EditionMicrobiology with Diseases by TaxonomyISBN: 9780134832302Non è quello che usi tu?Cambia libro di testo
Capitolo 16, Problema 2

MHC class II molecules bind to _________ and trigger __________ .
a. endogenous antigens; cytotoxic T cells
b. exogenous antigens; cytotoxic T cells
c. antibodies; B cells
d. endogenous antigens; helper T cells
e. exogenous antigens; helper T cells

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1
Understand the role of MHC class II molecules: MHC class II molecules are primarily found on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. Their main function is to present antigens to T cells.
Identify the type of antigens MHC class II molecules bind: MHC class II molecules present exogenous antigens, which are antigens that originate outside the cell and are taken up by the APC through processes like phagocytosis or endocytosis.
Determine which T cells interact with MHC class II: MHC class II molecules present these exogenous antigens to helper T cells (CD4+ T cells), which then become activated to coordinate the immune response.
Recall the function triggered by this interaction: When helper T cells recognize the antigen-MHC class II complex, they become activated and help stimulate other immune cells, such as B cells and cytotoxic T cells, to respond effectively.
Match the correct option based on the above information: MHC class II molecules bind to exogenous antigens and trigger helper T cells.

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MHC Class II Molecules

MHC class II molecules are proteins found on the surface of antigen-presenting cells like macrophages, dendritic cells, and B cells. They present processed exogenous antigens, which originate outside the cell, to the immune system. This presentation is crucial for initiating specific immune responses.
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07:17
Classes of MHC Molecules

Exogenous vs. Endogenous Antigens

Exogenous antigens come from outside the cell and are engulfed and processed by antigen-presenting cells, whereas endogenous antigens originate within infected or abnormal cells. MHC class II molecules present exogenous antigens, while MHC class I molecules present endogenous antigens.
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04:11
Free Antigens vs. Presented Antigens on APCs

Helper T Cells Activation

Helper T cells recognize antigens presented by MHC class II molecules and become activated. Once activated, they coordinate the immune response by stimulating other immune cells, such as B cells and cytotoxic T cells, to effectively combat pathogens.
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04:27
Review of Cytotoxic vs Helper T Cells
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3. ___ Th2 cell

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1. ___ Artificially acquired passive immunotherapy

2. ___ Naturally acquired active immunity

3. ___ Naturally acquired passive immunity

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d. A secondary immune response

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