Which bacterial structural component must be present for polymyxins to bind and initiate their disruptive action?

• A. Mycolic acid-rich cell walls found in mycobacteria.
• B. Lipopolysaccharide (LPS) in the outer membrane of Gram-negative bacteria.
• C. A eukaryotic-like cholesterol-rich membrane characteristic of fungi.
• D. Thick peptidoglycan layers typical of Gram-positive bacteria.

Answer: (B)