Design a prioritized intervention package for an outbreak of a zoonotic bacterial pathogen maintained in feral rodents that occasionally spills into farm workers. Which combined set of actions best addresses both reservoir control and human protection?

• A. Widespread distribution of N95 respirators to all rural residents and closure of regional markets for six months; because the pathogen is zoonotic, human personal respiratory protection alone is sufficient to prevent future spillovers without modifying the reservoir.
• B. Do nothing to the rodent population to avoid ecological consequences; instead, focus on long-term development of a novel vaccine that will be deployed in five years, assuming short-term transmission is negligible and can be tolerated.
• C. Immediate mass antibiotic prophylaxis for all workers, followed by relocation of entire farms and legal penalties for farmers who fail to cull nearby wildlife populations; this approach focuses on chemoprophylaxis and drastic ecological disruption as the fastest route to permanent elimination of the pathogen.
• D. Integrated rodent control (environmental sanitation and trapping around farms), targeted vaccination of livestock if available, worker education plus personal protective equipment (PPE) for farm workers and screening of symptomatic workers with prompt isolation, because this simultaneously reduces the nonhuman reservoir, lowers exposure, and contains human reservoirs to stop onward spread.

Answer: (D)