Chapter 16 Innate Immunity: Nonspecific Defenses of the Host

{"type":"doc","content":[{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Innate Immunity: Nonspecific Defenses of the Host"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Introduction to Immunity"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Immunity refers to the mechanisms by which the body defends itself against disease-causing microbes and environmental agents. There are two main types of immunity: innate (nonspecific) and adaptive (specific). Innate immunity provides immediate, broad protection, while adaptive immunity develops over time and targets specific pathogens."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Immunity:"},{"type":"text","text":" The ability to eliminate disease-causing microbes and protect against environmental agents (e.g., pollen)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Susceptibility:"},{"type":"text","text":" The lack of immunity to a particular agent."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Innate Immunity:"},{"type":"text","text":" Present at birth, provides routine protection against a wide range of pathogens."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Adaptive Immunity:"},{"type":"text","text":" Develops over time, provides protection against specific pathogens."}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_3.png","alt":"Overview of innate and adaptive immunity","title":null,"width":null,"height":null}}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Antigens & Antibodies"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Antigens and antibodies are central to the immune response. Antigens are foreign substances that induce an immune response, while antibodies are proteins that specifically recognize and bind to antigens, facilitating their removal."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Antigen:"},{"type":"text","text":" Any toxin or foreign substance that induces an antibody immune response."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Antibody:"},{"type":"text","text":" Y-shaped protein that recognizes and binds to an antigen, marking it for destruction by immune cells."}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_2.png","alt":"Antigens and antibodies trigger immune response","title":null,"width":null,"height":null}}]},{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Lines of Defense in Innate Immunity"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Overview of Innate Immunity"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Innate immunity consists of two main lines of defense. The first line includes physical, chemical, and microbiome barriers that prevent pathogen entry. The second line involves immune cells and molecular systems that detect and eliminate invaders that breach the first line."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"First-Line Defenses:"},{"type":"text","text":" Physical, chemical, and microbiome barriers that prevent microbe entry."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Second-Line Defenses:"},{"type":"text","text":" Immune cells and effectors that detect and eliminate microbes that bypass the first line."}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_5.png","alt":"Overview of immunity: first and second line defenses","title":null,"width":null,"height":null}}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"First-Line Defenses: Physical Barriers"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Physical barriers are the body's initial defense against infection. These include the skin and mucous membranes, which act as protective layers to block pathogen entry."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Skin:"},{"type":"text","text":" Composed of multiple layers, including the outer epidermis (keratinized, water-repellent, sheds microbes) and the inner dermis (connective tissue, tough and durable)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Mucous Membranes:"},{"type":"text","text":" Line the digestive, respiratory, and genitourinary tracts; produce mucus to trap and remove microbes."}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_9.png","alt":"Structure of the skin as a physical barrier","title":null,"width":null,"height":null}},{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_14.png","alt":"Mucous membranes structure and goblet cells","title":null,"width":null,"height":null}}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Mucociliary Escalator"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"The mucociliary escalator is a mechanism in the respiratory tract where cilia move mucus and trapped particles out of the airways, preventing infection."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Peristalsis:"},{"type":"text","text":" Intestinal contractions that move contents toward elimination."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Mucociliary Escalator:"},{"type":"text","text":" Cilia move mucus and trapped microbes out of the respiratory tract."}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_15.png","alt":"Mucociliary escalator in the respiratory tract","title":null,"width":null,"height":null}}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"First-Line Defenses: Chemical Barriers"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Chemical barriers include substances produced by the body that inhibit microbial growth or destroy microbes. These include sebum, sweat, earwax, saliva, gastric juices, and antimicrobial peptides."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Sebum:"},{"type":"text","text":" Oily substance from sebaceous glands; lowers skin pH and inhibits microbial growth."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Sweat:"},{"type":"text","text":" Contains lysozyme, an enzyme that degrades bacterial cell walls."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Earwax:"},{"type":"text","text":" Physically blocks entry and lowers pH to inhibit microbes."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Saliva:"},{"type":"text","text":" Contains lysozyme and other enzymes that inhibit microbial growth."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Gastric Juice:"},{"type":"text","text":" Highly acidic (pH ~2.5), destroys most ingested microbes and toxins."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Antimicrobial Peptides (AMPs):"},{"type":"text","text":" Short amino acid chains (e.g., defensins) that disrupt microbial membranes."}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_17.png","alt":"Sebaceous gland and its role in chemical defense","title":null,"width":null,"height":null}},{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_18.png","alt":"Earwax as a physical and chemical barrier","title":null,"width":null,"height":null}},{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_19.png","alt":"Sweat glands and their antimicrobial role","title":null,"width":null,"height":null}},{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_21.png","alt":"Salivary glands and antimicrobial action of saliva","title":null,"width":null,"height":null}},{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_23.png","alt":"Gastric juice and its acidic environment","title":null,"width":null,"height":null}}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"First-Line Defenses: Normal Microbiota"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"The normal microbiota (microbiome) consists of resident microbes that inhabit the body and play a crucial role in defending against pathogens by competing for attachment sites and producing antimicrobial substances."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Normal Microbiota:"},{"type":"text","text":" Resident microbes that protect against pathogens and are essential for immune development."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Probiotics:"},{"type":"text","text":" Live microbial cultures that benefit the normal microbiota."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Prebiotics:"},{"type":"text","text":" Chemicals that promote the growth of beneficial microbes."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Second-Line Defenses: Cells and Molecular Systems"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Cells of the Immune System"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Immune cells originate from hematopoietic stem cells in the bone marrow and differentiate into various types, including red blood cells, platelets, and white blood cells (leukocytes). Leukocytes are divided into granulocytes and agranulocytes."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Granulocytes:"},{"type":"text","text":" White blood cells with visible granules (neutrophils, eosinophils, basophils)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Agranulocytes:"},{"type":"text","text":" White blood cells without visible granules (monocytes, lymphocytes)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Granulocytes"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Neutrophils:"},{"type":"text","text":" Most abundant, first responders, phagocytic, contain hydrolytic enzymes and defensins."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Eosinophils:"},{"type":"text","text":" Defend against parasitic worms, involved in allergic reactions."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Basophils:"},{"type":"text","text":" Release histamine during inflammation, involved in allergic responses."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Mast Cells:"},{"type":"text","text":" Similar to basophils but reside in tissues."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":4},"content":[{"type":"text","text":"Agranulocytes"}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Monocytes:"},{"type":"text","text":" Circulate in blood, differentiate into macrophages and dendritic cells."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Macrophages:"},{"type":"text","text":" Phagocytic, reside in tissues, alert other immune cells."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Dendritic Cells:"},{"type":"text","text":" Sentinel cells, present antigens to adaptive immune cells."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Lymphocytes:"},{"type":"text","text":" Include B cells, T cells (adaptive immunity), and innate lymphoid cells (e.g., NK cells)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Cell Communication in Immunity"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Immune cells communicate via cell surface receptors, adhesion molecules, and cytokines to coordinate responses to infection."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Cell Surface Receptors:"},{"type":"text","text":" Proteins that detect external signals and trigger cellular responses."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Adhesion Molecules:"},{"type":"text","text":" Allow immune cells to attach to other cells and tissues, facilitating migration to infection sites."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Cytokines:"},{"type":"text","text":" Soluble proteins that regulate immune responses (e.g., chemokines, interleukins, interferons, TNF)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Pattern Recognition and the Complement System"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Pattern Recognition Receptors (PRRs)"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"PRRs are receptors on immune cells that detect molecular patterns associated with microbes (MAMPs/PAMPs) or host cell damage (DAMPs)."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Toll-Like Receptors (TLRs):"},{"type":"text","text":" Detect microbial molecules on cell surfaces or in endosomes/phagosomes."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"C-Type Lectin Receptors (CLRs):"},{"type":"text","text":" Bind carbohydrates on microbial surfaces."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"NOD-Like Receptors (NLRs):"},{"type":"text","text":" Cytoplasmic, detect intracellular MAMPs/DAMPs, form inflammasomes."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"RIG-Like Receptors (RLRs):"},{"type":"text","text":" Detect viral RNA in the cytoplasm."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"The Complement System"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"The complement system is a group of inactive proteins in the blood that, when activated, initiate a cascade of reactions leading to microbe removal and inflammation. It is part of innate immunity but also enhances adaptive responses."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Activation Pathways:"},{"type":"text","text":" Alternative, lectin, and classical pathways, all leading to the formation of C3 convertase."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Key Effects:"},{"type":"text","text":" Opsonization (C3b), cell lysis (membrane attack complex, MAC), and inflammatory response (C3a, C5a)."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Phagocytosis and Inflammation"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Phagocytosis"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Phagocytosis is the process by which immune cells engulf and digest microbes. Key steps include chemotaxis, recognition and attachment, engulfment, phagolysosome formation, destruction, and exocytosis."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Phagocytes:"},{"type":"text","text":" Macrophages, neutrophils, dendritic cells."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Opsonization:"},{"type":"text","text":" Coating of microbes with opsonins (e.g., C3b) to enhance phagocytosis."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Inflammation"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Inflammation is a coordinated response to infection or tissue damage, characterized by swelling, heat, altered function, redness, and pain. It can be acute (short-term) or chronic (long-term)."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Acute Inflammation:"},{"type":"text","text":" Rapid onset, short duration, neutrophil recruitment."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Chronic Inflammation:"},{"type":"text","text":" Slow onset, long duration, macrophages, giant cells, and T lymphocytes form granulomas."}]}]}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"https://static.studychannel.pearsonprd.tech/study_guide_files/microbiology/sub_images/c35552b8_image_4.png","alt":"Cardinal signs of inflammation","title":null,"width":null,"height":null}}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Steps of the Inflammatory Response"}]},{"type":"orderedList","attrs":{"start":1,"type":null},"content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Tissue damage and infection"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Release of inflammatory mediators (e.g., histamine)"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Vasodilation and diapedesis (immune cell migration)"}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Removal of invading microbes and damaged tissue"}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":2},"content":[{"type":"text","text":"Fever and Interferon Response"}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Fever"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Fever is an elevated body temperature (above 37.8°C) that inhibits microbial growth and enhances immune responses. It is triggered by pyrogens (endogenous or exogenous)."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Pyrogens:"},{"type":"text","text":" Fever-inducing cytokines (e.g., IL-1, TNF) or microbial products (e.g., LPS)."}]}]},{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Effects:"},{"type":"text","text":" Inhibits pathogen growth, increases immune efficiency."}]}]}]},{"type":"heading","attrs":{"textAlign":null,"level":3},"content":[{"type":"text","text":"Interferon Response"}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","text":"Interferons (IFNs) are cytokines that provide antiviral protection by warning neighboring cells to produce antiviral proteins (AVPs). If a cell is infected, AVPs are activated, leading to apoptosis and preventing viral replication."}]},{"type":"bulletList","content":[{"type":"listItem","content":[{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"Steps:"},{"type":"text","text":" Viral RNA detection → IFN production → Neighboring cells produce iAVPs → Infection triggers AVP activation and apoptosis."}]},{"type":"paragraph","attrs":{"textAlign":null},"content":[{"type":"image","attrs":{"src":"data:image/png;base64,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