Question 1

Which of the following best describes the genome and capsid structure of Herpesviridae?

Accepted Answer

Double-stranded DNA, enveloped, icosahedral

Question 2

A patient presents with a painful blister on their finger after caring for a child with oral herpes. What is the most likely diagnosis?

Accepted Answer

Whitlow

Question 3

Which herpesvirus is most commonly associated with genital herpes infections?

Accepted Answer

HHV-2

Question 4

A child develops a pink rash on the face, neck, trunk, and thighs, and later tests positive for HHV-6. What is the name of this disease?

Accepted Answer

Roseola

Question 5

Which of the following is a characteristic finding in cells infected with cytomegalovirus (CMV)?

Accepted Answer

Owl's eye inclusions

Question 6

A 25-year-old presents with fever, sore throat, and lymphadenopathy. Laboratory tests reveal atypical lymphocytes. Which virus is most likely responsible?

Accepted Answer

Epstein-Barr virus (EBV)

Question 7

Which of the following best explains why chickenpox can later cause shingles?

Accepted Answer

The virus remains latent in sensory ganglia and reactivates

Question 8

Which of the following is the primary mode of transmission for HHV-4 (Epstein-Barr virus)?

Accepted Answer

Saliva

Question 9

A newborn develops severe systemic infection shortly after birth. The mother had active genital lesions at delivery. Which virus is most likely responsible?

Accepted Answer

HHV-2

Question 10

Which of the following is a cancer associated with HHV-8 infection, especially in immunocompromised patients?

Accepted Answer

Kaposi's sarcoma

Question 11

Which of the following best describes the mechanism by which herpesviruses spread from cell to cell?

Accepted Answer

Formation of syncytia

Question 12

A patient with AIDS develops pneumonia and visual impairment. Laboratory tests reveal the presence of large cells with 'owl's eye' inclusions. Which virus is most likely responsible?

Accepted Answer

HHV-5 (Cytomegalovirus)

Question 13

Which of the following is the most effective prevention strategy for health care workers to avoid herpetic whitlow?

Accepted Answer

Wearing gloves during patient care

Question 14

Which of the following statements about the latency of herpesviruses is correct?

Accepted Answer

Latent viruses remain inactive in specific ganglia and can reactivate

Question 15

A patient with a history of chickenpox develops a painful, unilateral rash along a single dermatome. What is the most likely diagnosis?

Accepted Answer

Shingles (herpes zoster)

Question 16

Which of the following best explains why chickenpox is difficult to prevent through isolation of infected individuals?

Accepted Answer

The virus is shed before obvious signs appear

Question 17

Which of the following is a common complication of cytomegalovirus infection in newborns?

Accepted Answer

Blindness and hearing loss

Question 18

Which of the following best describes the immune response that leads to the symptoms of infectious mononucleosis caused by EBV?

Accepted Answer

Cytotoxic T cells killing virus-infected B lymphocytes

Question 19

Which of the following is the most common site of latency for HHV-1?

Accepted Answer

Trigeminal and brachial ganglia

Question 20

A patient with poor cellular immunity develops oral hairy leukoplakia. Which virus is most likely responsible?

Accepted Answer

HHV-4 (Epstein-Barr virus)

Pathogenic DNA Viruses: Herpesviridae and Related Human Diseases

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