Question 1

Which of the following DNA virus families is unique in that it replicates in the cytoplasm rather than the nucleus of the host cell?

Accepted Answer

Poxviridae

Question 2

A patient presents with smooth, waxy papules on the trunk and face. Which virus is most likely responsible for this condition?

Accepted Answer

Molluscipoxvirus

Question 3

Which of the following characteristics contributed most to the eradication of smallpox?

Accepted Answer

Obvious symptoms and lack of asymptomatic cases

Question 4

Which of the following is TRUE regarding the genome of Hepadnaviridae (e.g., hepatitis B virus)?

Accepted Answer

It has a partial single and partial double-stranded DNA genome

Question 5

A laboratory technician is examining a virus with a naked, icosahedral capsid and a diameter of 45–55 nm. Which virus family is most likely being observed?

Accepted Answer

Papillomaviridae

Question 6

Which of the following best describes the progression of lesions in a typical poxvirus infection?

Accepted Answer

Macule → Papule → Vesicle → Pustule → Crust → Scar

Question 7

Which of the following viruses is associated with the development of progressive multifocal leukoencephalopathy (PML) in immunocompromised patients?

Accepted Answer

JC virus

Question 8

A sexually active adult presents with genital warts. Which virus is most likely responsible, and what is a significant long-term risk associated with this infection?

Accepted Answer

Papillomavirus; increased risk of cancer

Question 9

Which of the following is NOT a reason why smallpox was easier to eradicate compared to other viral diseases?

Accepted Answer

It had a high rate of asymptomatic infections

Question 10

Which of the following statements about the replication of most DNA viruses is correct?

Accepted Answer

Most DNA viruses replicate in the nucleus

Question 11

A child presents with a mild rash and is diagnosed with fifth disease. Which virus family is responsible for this illness?

Accepted Answer

Parvoviridae

Question 12

Which of the following best explains why beta interferon is used in the treatment of BK virus infections?

Accepted Answer

It prevents kidney damage by inhibiting viral replication

Question 13

Which of the following is a distinguishing feature of the Poxviridae family compared to other DNA viruses?

Accepted Answer

They have complex capsids and replicate in the cytoplasm

Question 14

A patient with AIDS develops numerous waxy papules on the skin. Which virus is most likely responsible, and what is the recommended treatment?

Accepted Answer

Molluscipoxvirus; removal of infected nodules

Question 15

Which of the following viruses is most commonly associated with conjunctivitis and respiratory infections?

Accepted Answer

Adenovirus

Question 16

Which of the following is the most common sexually transmitted infection (STI) in the United States?

Accepted Answer

Human papillomavirus (HPV)

Question 17

Which of the following best describes the outcome of polyomavirus infection in immunocompetent versus immunocompromised individuals?

Accepted Answer

Immunocompetent individuals prevent latent infections; immunocompromised individuals may develop kidney or CNS disease

Question 18

Which of the following is a key difference between Papillomaviridae and Polyomaviridae?

Accepted Answer

Papillomaviridae cause benign tumors, Polyomaviridae can cause tumors and other diseases

Question 19

Which of the following equations correctly represents the transcription process for a parvovirus (ssDNA) in a host cell?

Accepted Answer

$$\mathrm{ssDNA} \rightarrow \mathrm{mRNA}$$

Question 20

Which of the following is a plausible reason for the increase in monkeypox cases in humans over the past decade?

Accepted Answer

Increased contact with infected animals

Pathogenic DNA Viruses: Structure, Classification, and Human Diseases

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