Two sweeteners are being compared for reformulation: Sweetener M is 300× sweeter with an ADI of 12 mg/kg, and Sweetener N is 900× sweeter with an ADI of 5 mg/kg. For a population average body weight of 70 kg and a beverage containing 15 g sucrose per serving, which sweetener allows more servings per day before exceeding its ADI? Show your reasoning.

• A. You cannot compare servings allowed because ADIs are not comparable across compounds; therefore no answer can be calculated.
• B. Both allow exactly the same number of servings because the product of relative sweetness and ADI is always constant across sweeteners.
• C. Sweetener M allows more servings because its higher ADI numerically compensates for its lower potency, resulting in more servings than N.
• D. Sweetener N allows more servings per day (about 21 servings) compared to Sweetener M (about 16 servings), because N requires less mass per serving despite a lower ADI.

Answer: (D)